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Literature summary for 1.1.1.146 extracted from
- An in vitro microdialysis methodology to study 11beta-hydroxysteroid dehydrogenase type 1 enzyme activity in liver microsomes (2007), Anal. Biochem., 370, 26-37.
Application
| Application | Comment | Organism |
|---|---|---|
| analysis | use of microdialysis sampling coupled with liquid chromatography/electrospray ionization mass spectrometry to study 11beta-hydroxysteroid dehydrogenase type 1 catalyzed conversion of stable-isotope-labeled cortisone to cortisol in liver microsome. Results show species-specific reaction profiles, with a five times higher coversion rate in dog than in human and monkey liver microsome | Homo sapiens |
| analysis | use of microdialysis sampling coupled with liquid chromatography/electrospray ionization mass spectrometry to study 11beta-hydroxysteroid dehydrogenase type 1 catalyzed conversion of stable-isotope-labeled cortisone to cortisol in liver microsome. Results show species-specific reaction profiles, with a five times higher coversion rate in dog than in human and monkey liver microsome | Canis lupus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Homo sapiens | - |
- |
| microsome | - |
Canis lupus | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Canis lupus | - |
- |
- |
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | species-specific reaction profiles of 11beta-hydroxysteroid dehydrogenase, with a five times higher conversion rate in dog than in human and monkey liver microsome | Homo sapiens | - |
| liver | species-specific reaction profiles of 11beta-hydroxysteroid dehydrogenase, with a five times higher conversion rate in dog than in human and monkey liver microsome | Canis lupus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cortisone + NADPH + H+ | - |
Homo sapiens | cortisol + NADP+ | - |
? |  |
| cortisone + NADPH + H+ | - |
Canis lupus | cortisol + NADP+ | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADP+ | - |
Homo sapiens | |
| NADP+ | - |
Canis lupus | |
| NADPH | - |
Homo sapiens | |
| NADPH | - |
Canis lupus | |
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Release 2023.1 (January 2023)
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