Cloned (Comment) | Organism |
---|---|
expression in CHO cells | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3beta-hydroxy-11-oxo-18beta-olean-12-en-30-oic-acid | i.e. glycyrrhetinic acid; more effective for 11-dehydrogenase than for 11-oxoreductase activity | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH | Rattus norvegicus | i.e. cortisone, stable dehydrogenase activity, unstable oxidoreductase activity | 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ | i.e. cortisol | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH | i.e. cortisone, stable dehydrogenase activity, unstable oxidoreductase activity | Rattus norvegicus | 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ | i.e. cortisol | ? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Rattus norvegicus |