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Literature summary for 1.1.1.146 extracted from

  • Monder, C.
    The forms and functions of 11beta-hydroxysteroid dehydrogenase (1993), J. Steroid Biochem. Mol. Biol., 45, 161-165.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in CHO cells Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
3beta-hydroxy-11-oxo-18beta-olean-12-en-30-oic-acid i.e. glycyrrhetinic acid; more effective for 11-dehydrogenase than for 11-oxoreductase activity Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH Rattus norvegicus i.e. cortisone, stable dehydrogenase activity, unstable oxidoreductase activity 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ i.e. cortisol ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH i.e. cortisone, stable dehydrogenase activity, unstable oxidoreductase activity Rattus norvegicus 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ i.e. cortisol ?

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Rattus norvegicus