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Literature summary for 1.1.1.145 extracted from

  • Sun, W.; Huang, Y.; Zhao, Z.; Gui, J.; Zhang, Q.
    Characterization of the Rana grylio virus 3beta-hydroxysteroid dehydrogenase and its novel role in suppressing virus-induced cytopathic effect (2006), Biochem. Biophys. Res. Commun., 351, 44-50.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid sequence determination and analysis, transient and stable expression of the virus enzyme in Epithelioma papulosum cyprini cells, expression as EGFP-fusion protein exclusively in host cell mitochondria, enzyme overexpression does not influence viral replication or cell growth, but does suppress virus-induced cytopathic effects Rana grylio iridovirus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DELTA5-3beta-hydroxysteroid + NAD+ Rana grylio iridovirus the enzyme is essential for biosynthesis of all classes of steroid hormones DELTA4-3-oxosteroid + NADH + H+
-
?
DELTA5-3beta-hydroxysteroid + NAD+ Rana grylio iridovirus 9506 the enzyme is essential for biosynthesis of all classes of steroid hormones DELTA4-3-oxosteroid + NADH + H+
-
?

Organism

Organism UniProt Comment Textmining
Rana grylio iridovirus Q0G9Z6 i.e. RGV, 9506
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Rana grylio iridovirus 9506 Q0G9Z6 i.e. RGV, 9506
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DELTA5-3beta-hydroxysteroid + NAD+ the enzyme is essential for biosynthesis of all classes of steroid hormones Rana grylio iridovirus DELTA4-3-oxosteroid + NADH + H+
-
?
DELTA5-3beta-hydroxysteroid + NAD+ the enzyme performs the 3beta-hydroxysteroid dehydrogenase and DELTA5-DELTA4 isomerase reactions Rana grylio iridovirus DELTA4-3-oxosteroid + NADH + H+
-
?
DELTA5-3beta-hydroxysteroid + NAD+ the enzyme is essential for biosynthesis of all classes of steroid hormones Rana grylio iridovirus 9506 DELTA4-3-oxosteroid + NADH + H+
-
?
DELTA5-3beta-hydroxysteroid + NAD+ the enzyme performs the 3beta-hydroxysteroid dehydrogenase and DELTA5-DELTA4 isomerase reactions Rana grylio iridovirus 9506 DELTA4-3-oxosteroid + NADH + H+
-
?

Synonyms

Synonyms Comment Organism
3beta-HSD
-
Rana grylio iridovirus
3beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4 isomerase
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Rana grylio iridovirus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Rana grylio iridovirus