Literature summary for 1.1.1.145 extracted from

Coirini, H.; Gouezou, M.; Delespierre, B.; Liere, P.; Pianos, A.; Eychenne, B.; Schumacher, M.; Guennoun, R.
Characterization and regulation of the 3beta-hydroxysteroid dehydrogenase isomerase enzyme in the rat sciatic nerve (2003), J. Neurochem., 84, 119-126.

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Inhibitors

Inhibitors	Comment	Organism	Structure
corticosterone	0.08 mM, 50% inhibition	Rattus norvegicus
oestradiol	0.00024 mM, 50% inhibition	Rattus norvegicus
progesterone	0.026 mM, 50% inhibition	Rattus norvegicus
testosterone	0.0086 mM, 50% inhibition	Rattus norvegicus
trilostane	0.004 mM, 50% inhibition	Rattus norvegicus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.001	-	pregnenolone	37°C	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
pregnenolone + NAD+	Rattus norvegicus	-	pregn-5-en-3,20-dione + NADH + H+	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
sciatic nerve	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
pregnenolone + NAD+	-	Rattus norvegicus	pregn-5-en-3,20-dione + NADH + H+	-	?

Synonyms

Synonyms	Comment	Organism
3beta-HSD	-	Rattus norvegicus

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Release 2023.1 (January 2023)