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Literature summary for 1.1.1.145 extracted from

  • Labrie, F.; Simard, J.; Luu-The, V.; Pelletier, G.; Belanger, A.; Lachance, Y.; Zhao, H.F.; Labrie, C.; Breton, N.; de Launoit, Y.; et al.
    Structure and tissue-specific expression of 3beta-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase genes in human and rat classical and peripheral steroidogenic tissues (1992), J. Steroid Biochem. Mol. Biol., 41, 421-435.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
transient expression of HSD I and II cDNA in HeLa cells Homo sapiens
transient expression of HSD I and II cDNA in HeLa cells Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pregnenolone + NAD(P)+ Homo sapiens
-
pregn-5-en-3,20-dione + NAD(P)H + H+
-
?
pregnenolone + NAD(P)+ Rattus norvegicus
-
pregn-5-en-3,20-dione + NAD(P)H + H+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue
-
Rattus norvegicus
-
adrenal gland
-
Rattus norvegicus
-
adrenal gland 3beta-HSD II Homo sapiens
-
ovary
-
Rattus norvegicus
-
ovary 3beta-HSD II Homo sapiens
-
placenta 3beta-HSD I Homo sapiens
-
skin 3beta-HSD I Homo sapiens
-
testis
-
Rattus norvegicus
-
testis 3beta-HSD II Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3beta,17alpha-dihydroxy-5-pregnen-20-one + NAD(P)+
-
Homo sapiens 17alpha-hydroxypregn-5-ene-3,20-dione + NAD(P)H
-
?
3beta,17alpha-dihydroxy-5-pregnen-20-one + NAD(P)+
-
Rattus norvegicus 17alpha-hydroxypregn-5-ene-3,20-dione + NAD(P)H
-
?
pregnenolone + NAD(P)+
-
Homo sapiens pregn-5-en-3,20-dione + NAD(P)H + H+
-
?
pregnenolone + NAD(P)+
-
Rattus norvegicus pregn-5-en-3,20-dione + NAD(P)H + H+
-
?

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens
NAD+
-
Rattus norvegicus