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Literature summary for 1.1.1.145 extracted from

  • Cherradi, N.; Defaye, G.; Chambaz, E.M.
    Characterization of the 3beta-hydroxysteroid dehydrogenase activity associated with bovine adrenocortical mitochondria (1994), Endocrinology, 134, 1358-1364.
    View publication on PubMed
Search for more literature for 1.1.1.145

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0016
-
 dehydroepiandrosterone microsomes Bos taurus
0.002
-
 pregnenolone mitochondria Bos taurus
0.0032
-
 pregnenolone microsomes Bos taurus
0.0045
-
 dehydroepiandrosterone mitochondria Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Bos taurus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dehydroepiandrosterone + NAD+ Bos taurus
-
 androst-5-en-3,17-dione + NADH + H+
-
 ?
pregnenolone + NAD(P)+ Bos taurus
-
 pregn-5-en-3,20-dione + NAD(P)H + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0043
-
 mitochondria Bos taurus
0.0158
-
 microsomes Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3beta,17alpha-dihydroxy-5-pregnen-20-one + NAD(P)+
-
 Bos taurus 17alpha-hydroxypregn-5-ene-3,20-dione + NAD(P)H
-
 ?
dehydroepiandrosterone + NAD+
-
 Bos taurus androst-5-en-3,17-dione + NADH + H+
-
 ?
pregnenolone + NAD(P)+
-
 Bos taurus pregn-5-en-3,20-dione + NAD(P)H + H+
-
 ?

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Bos taurus