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Literature summary for 1.1.1.145 extracted from

  • Thomas, J.L.; Evans, B.W.; Blanco, G.; Mason, J.I.; Strickler, R.C.
    Creation of a fully active, cytosolic form of human type I 3beta-hydroxysteroid dehydrogenase/isomerase by the deletion of a membrane-spanning domain (1999), J. Mol. Endocrinol., 23, 231-239.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
overexpression with his6-tag, using a baculovirus expression system Homo sapiens

Protein Variants

Protein Variants Comment Organism
DELTA283-310 cytosolic enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pregnenolone + NAD(P)+ Homo sapiens
-
pregn-5-en-3,20-dione + NAD(P)H + H+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
3beta-HSD II
-
Homo sapiens
-
3beta-HSD I
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland 3beta-HSD II Homo sapiens
-
ovary 3beta-HSD II Homo sapiens
-
placenta 3beta-HSD I Homo sapiens
-
testis 3beta-HSD II Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0062
-
wild type, microsomes Homo sapiens
0.0099
-
wild type, mitochondria Homo sapiens
0.0225
-
283-310 deletion, cytosol Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3beta,17alpha-dihydroxy-5-pregnen-20-one + NAD(P)+
-
Homo sapiens 17alpha-hydroxypregn-5-ene-3,20-dione + NAD(P)H
-
?
pregnenolone + NAD(P)+
-
Homo sapiens pregn-5-en-3,20-dione + NAD(P)H + H+
-
?

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens