Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(1-butyl-1H-benzimidazol-5-yl)(piperidin-1-yl)methanone | - |
Homo sapiens | |
(1-phenyl-1H-benzimidazol-5-yl)(piperidin-1-yl)methanone | - |
Homo sapiens | |
(1-tert-butyl-1H-benzimidazol-5-yl)(piperidin-1-yl)methanone | - |
Homo sapiens | |
(3,3-dimethylpiperidin-1-yl)[1-(3-methylphenyl)-1H-benzimidazol-5-yl]methanone | - |
Homo sapiens | |
(3,5-dimethylpiperidin-1-yl)[1-(3-methylphenyl)-1H-benzimidazol-5-yl]methanone | - |
Homo sapiens | |
(4-bromopiperidin-1-yl)[1-(3-methylphenyl)-1H-benzimidazol-5-yl]methanone | - |
Homo sapiens | |
(piperidin-1-yl)[1-[3-(propan-2-yl)phenyl]-1H-benzimidazol-5-yl]methanone | - |
Homo sapiens | |
(piperidin-1-yl)[1-[3-(trifluoromethyl)phenyl]-1H-benzimidazol-5-yl]methanone | - |
Homo sapiens | |
(piperidin-1-yl)[1-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-5-yl]methanone | - |
Homo sapiens | |
2-[[(6-bromo-3H-imidazo[4,5-b]pyridin-2-yl)sulfanyl]methyl]benzonitrile | - |
Homo sapiens | |
3-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)-5,6,7,8,9,10-hexahydro[1,2,4]triazolo[4,3-a]azocine | - |
Homo sapiens | |
3-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine | - |
Homo sapiens | |
3-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)-6,7,8,9,10,11-hexahydro-5H-[1,2,4]triazolo[4,3-a]azonine | - |
Homo sapiens | |
3-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)-6,7,8,9-tetrahydro-5H-pyrrolo[1,2-a]azepine | - |
Homo sapiens | |
3-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazole | - |
Homo sapiens | |
3-[1-(3,4-dichlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine | - |
Homo sapiens | |
3-[1-(3-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine | - |
Homo sapiens | |
3-[1-(4-bromophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine | - |
Homo sapiens | |
3-[1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine | - |
Homo sapiens | |
3-[1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine | - |
Homo sapiens | |
3-[1-(4-methoxyphenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine | - |
Homo sapiens | |
3-[1-(4-tert-butylphenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine | - |
Homo sapiens | |
3-[2,5-dimethyl-1-(4-methylphenyl)-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine | - |
Homo sapiens | |
3-[2,5-dimethyl-1-(4-nitrophenyl)-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine | - |
Homo sapiens | |
3-[2,5-dimethyl-1-[3-(trifluoromethyl)phenyl]-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine | - |
Homo sapiens | |
3-[2,5-dimethyl-1-[4-(naphthalen-2-yl)phenyl]-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine | - |
Homo sapiens | |
3-[2,5-dimethyl-1-[4-(pyridin-2-yl)phenyl]-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine | - |
Homo sapiens | |
3-[2,5-dimethyl-1-[4-(pyridin-3-yl)phenyl]-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine | - |
Homo sapiens | |
3-[2,5-dimethyl-1-[4-(pyridin-4-yl)phenyl]-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine | - |
Homo sapiens | |
3-[2,5-dimethyl-1-[4-(trifluoromethyl)phenyl]-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine | - |
Homo sapiens | |
3-[2,5-dimethyl-3-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-yl)-1H-pyrrol-1-yl]benzonitrile | - |
Homo sapiens | |
4-[2,5-dimethyl-3-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-yl)-1H-pyrrol-1-yl]benzonitrile | - |
Homo sapiens | |
ethyl 4-[2,5-dimethyl-3-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-yl)-1H-pyrrol-1-yl]benzoate | - |
Homo sapiens | |
N,N-diethyl-1-(3-methylphenyl)-1H-benzimidazole-5-carboxamide | - |
Homo sapiens | |
N-butyl-1-(3-methylphenyl)-1H-benzimidazole-5-carboxamide | - |
Homo sapiens | |
N-cyclopentyl-1-(3-methylphenyl)-1H-benzimidazole-5-carboxamide | - |
Homo sapiens | |
[1-(2-methoxyphenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone | - |
Homo sapiens | |
[1-(3-chlorophenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone | - |
Homo sapiens | |
[1-(3-methoxyphenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone | - |
Homo sapiens | |
[1-(3-methylphenyl)-1H-benzimidazol-5-yl](3-methylpiperidin-1-yl)methanone | - |
Homo sapiens | |
[1-(3-methylphenyl)-1H-benzimidazol-5-yl](3-phenylpiperidin-1-yl)methanone | - |
Homo sapiens | |
[1-(3-methylphenyl)-1H-benzimidazol-5-yl](4-methylpiperazin-1-yl)methanone | - |
Homo sapiens | |
[1-(3-methylphenyl)-1H-benzimidazol-5-yl](morpholin-4-yl)methanone | - |
Homo sapiens | |
[1-(3-methylphenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone | - |
Homo sapiens | |
[1-(3-methylphenyl)-1H-benzimidazol-5-yl](pyrrolidin-1-yl)methanone | - |
Homo sapiens | |
[1-(3-methylphenyl)-1H-benzimidazol-5-yl][3-(propan-2-yl)piperidin-1-yl]methanone | - |
Homo sapiens | |
[1-(3-methylphenyl)-1H-benzimidazol-5-yl][3-(trifluoromethyl)piperidin-1-yl]methanone | - |
Homo sapiens | |
[1-(3-methylphenyl)-1H-benzimidazol-5-yl][4-(trifluoromethyl)piperidin-1-yl]methanone | - |
Homo sapiens | |
[1-(3-tert-butylphenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone | - |
Homo sapiens | |
[1-(4-chlorophenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone | - |
Homo sapiens | |
[1-(4-methoxyphenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone | - |
Homo sapiens | |
[1-(4-methylphenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone | - |
Homo sapiens | |
[1-(4-tert-butylphenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P15428 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
LNCaP cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
prostaglandin E2 + NAD+ | - |
Homo sapiens | 15-oxoprostaglandin E2 + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
15-PGDH | - |
Homo sapiens |
HPGD | - |
Homo sapiens |
NAD+-dependent 15-hydroxyprostaglandin dehydrogenase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000012 | - |
pH and temperature not specified in the publication | Homo sapiens | [1-(3-chlorophenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone | |
0.000019 | - |
pH and temperature not specified in the publication | Homo sapiens | [1-(3-methylphenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone | |
0.000019 | - |
pH and temperature not specified in the publication | Homo sapiens | [1-(3-methoxyphenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone | |
0.000022 | - |
pH and temperature not specified in the publication | Homo sapiens | (1-phenyl-1H-benzimidazol-5-yl)(piperidin-1-yl)methanone | |
0.000022 | - |
pH and temperature not specified in the publication | Homo sapiens | [1-(3-methylphenyl)-1H-benzimidazol-5-yl](3-methylpiperidin-1-yl)methanone | |
0.000022 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-[1-(3,4-dichlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine | |
0.000027 | - |
pH and temperature not specified in the publication | Homo sapiens | [1-(2-methoxyphenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone | |
0.000034 | - |
pH and temperature not specified in the publication | Homo sapiens | (1-tert-butyl-1H-benzimidazol-5-yl)(piperidin-1-yl)methanone | |
0.000034 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-[1-(3-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine | |
0.000034 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-[2,5-dimethyl-1-(4-methylphenyl)-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine | |
0.000038 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-[1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine | |
0.000038 | - |
pH and temperature not specified in the publication | Homo sapiens | ethyl 4-[2,5-dimethyl-3-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-yl)-1H-pyrrol-1-yl]benzoate | |
0.000048 | - |
pH and temperature not specified in the publication | Homo sapiens | (piperidin-1-yl)[1-[3-(trifluoromethyl)phenyl]-1H-benzimidazol-5-yl]methanone | |
0.000048 | - |
pH and temperature not specified in the publication | Homo sapiens | [1-(3-methylphenyl)-1H-benzimidazol-5-yl][3-(propan-2-yl)piperidin-1-yl]methanone | |
0.000048 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-[1-(4-bromophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine | |
0.000048 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-[2,5-dimethyl-1-[3-(trifluoromethyl)phenyl]-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine | |
0.000054 | - |
pH and temperature not specified in the publication | Homo sapiens | [1-(4-tert-butylphenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone | |
0.000054 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)-6,7,8,9-tetrahydro-5H-pyrrolo[1,2-a]azepine | |
0.000068 | - |
pH and temperature not specified in the publication | Homo sapiens | (1-butyl-1H-benzimidazol-5-yl)(piperidin-1-yl)methanone | |
0.000068 | - |
pH and temperature not specified in the publication | Homo sapiens | (3,3-dimethylpiperidin-1-yl)[1-(3-methylphenyl)-1H-benzimidazol-5-yl]methanone | |
0.000068 | - |
pH and temperature not specified in the publication | Homo sapiens | (piperidin-1-yl)[1-[3-(propan-2-yl)phenyl]-1H-benzimidazol-5-yl]methanone | |
0.000068 | - |
pH and temperature not specified in the publication | Homo sapiens | [1-(3-methylphenyl)-1H-benzimidazol-5-yl][3-(trifluoromethyl)piperidin-1-yl]methanone | |
0.000068 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-[2,5-dimethyl-1-[4-(trifluoromethyl)phenyl]-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine | |
0.000076 | - |
pH and temperature not specified in the publication | Homo sapiens | (4-bromopiperidin-1-yl)[1-(3-methylphenyl)-1H-benzimidazol-5-yl]methanone | |
0.000076 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-[2,5-dimethyl-3-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-yl)-1H-pyrrol-1-yl]benzonitrile | |
0.000086 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-[1-(4-methoxyphenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine | |
0.000096 | - |
pH and temperature not specified in the publication | Homo sapiens | 4-[2,5-dimethyl-3-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-yl)-1H-pyrrol-1-yl]benzonitrile | |
0.000108 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-[2,5-dimethyl-1-(4-nitrophenyl)-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine | |
0.000108 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-[2,5-dimethyl-1-[4-(naphthalen-2-yl)phenyl]-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine | |
0.000121 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-[1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine | |
0.000136 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-[1-(4-tert-butylphenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine | |
0.000171 | - |
pH and temperature not specified in the publication | Homo sapiens | [1-(3-tert-butylphenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone | |
0.00019 | - |
pH and temperature not specified in the publication | Homo sapiens | [1-(4-methoxyphenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone | |
0.00019 | - |
pH and temperature not specified in the publication | Homo sapiens | [1-(4-methylphenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone | |
0.000192 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine | |
0.00022 | - |
pH and temperature not specified in the publication | Homo sapiens | [1-(4-chlorophenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone | |
0.000242 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)-5,6,7,8,9,10-hexahydro[1,2,4]triazolo[4,3-a]azocine | |
0.000271 | - |
pH and temperature not specified in the publication | Homo sapiens | (3,5-dimethylpiperidin-1-yl)[1-(3-methylphenyl)-1H-benzimidazol-5-yl]methanone | |
0.000271 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-[2,5-dimethyl-1-[4-(pyridin-3-yl)phenyl]-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine | |
0.000383 | - |
pH and temperature not specified in the publication | Homo sapiens | [1-(3-methylphenyl)-1H-benzimidazol-5-yl](pyrrolidin-1-yl)methanone | |
0.000383 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)-6,7,8,9,10,11-hexahydro-5H-[1,2,4]triazolo[4,3-a]azonine | |
0.000383 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-[2,5-dimethyl-1-[4-(pyridin-4-yl)phenyl]-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine | |
0.000383 | - |
pH and temperature not specified in the publication | Homo sapiens | N,N-diethyl-1-(3-methylphenyl)-1H-benzimidazole-5-carboxamide | |
0.000429 | - |
pH and temperature not specified in the publication | Homo sapiens | [1-(3-methylphenyl)-1H-benzimidazol-5-yl](3-phenylpiperidin-1-yl)methanone | |
0.00086 | - |
pH and temperature not specified in the publication | Homo sapiens | (piperidin-1-yl)[1-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-5-yl]methanone | |
0.000961 | - |
pH and temperature not specified in the publication | Homo sapiens | N-cyclopentyl-1-(3-methylphenyl)-1H-benzimidazole-5-carboxamide | |
0.001078 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-[2,5-dimethyl-1-[4-(pyridin-2-yl)phenyl]-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine | |
0.001358 | - |
pH and temperature not specified in the publication | Homo sapiens | N-butyl-1-(3-methylphenyl)-1H-benzimidazole-5-carboxamide | |
0.001524 | - |
pH and temperature not specified in the publication | Homo sapiens | [1-(3-methylphenyl)-1H-benzimidazol-5-yl][4-(trifluoromethyl)piperidin-1-yl]methanone | |
0.00271 | - |
pH and temperature not specified in the publication | Homo sapiens | [1-(3-methylphenyl)-1H-benzimidazol-5-yl](4-methylpiperazin-1-yl)methanone | |
0.00304 | - |
pH and temperature not specified in the publication | Homo sapiens | [1-(3-methylphenyl)-1H-benzimidazol-5-yl](morpholin-4-yl)methanone | |
0.00304 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazole |