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Literature summary for 1.1.1.141 extracted from

  • Liu, Y.; Jia, Z.; Sun, Y.; Zhou, L.; Downton, M.; Chen, R.; Zhang, A.; Yang, T.
    Postnatal regulation of 15-hydroxyprostaglandin dehydrogenase in the rat kidney (2014), Am. J. Physiol. Renal Physiol., 307, F388-F395.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ Rattus norvegicus
-
 (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
-
 Rattus norvegicus (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?

Synonyms

Synonyms Comment Organism
15-PGDH
-
 Rattus norvegicus
NAD+-dependent 15-hydroxyprostaglandin dehydrogenase
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Rattus norvegicus

General Information

General Information Comment Organism
physiological function the enzyme regulates postnatal kidney development through interaction with cyclooxygenase 2 Rattus norvegicus