Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.141 extracted from

  • Cho, H.; Tai, H.H.
    Inhibition of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH) by cyclooxygenase inhibitors and chemopreventive agents (2002), Prostaglandins, 67, 461-465.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
15-deoxy-DELTA12,14-prostaglandin J2 0.024 mM, 50% inhibition Homo sapiens
Berberine 0.023 mM, 50% inhibition Homo sapiens
Biochanin A 0.031 mM, 50% inhibition Homo sapiens
chalcone 0.016 mM, 50% inhibition Homo sapiens
chrysin 0.021 mM, 50% inhibition Homo sapiens
ciglitazone 0.003 mM, 50% inhibition Homo sapiens
curcumin 0.01 mM, 50% inhibition Homo sapiens
DuP 697 0.022 mM, 50% inhibition Homo sapiens
epigallocatechin gallate 0.012 mM, 50% inhibition Homo sapiens
Flufenamic acid 0.041 mM, 50% inhibition Homo sapiens
flurbiprofen 0.062 mM, 50% inhibition Homo sapiens
indomethacin 0.066 mM, 50% inhibition Homo sapiens
ketorolac 0.028 mM, 50% inhibition Homo sapiens
Meclofenamic acid 0.073 mM, 50% inhibition Homo sapiens
Mefenamic acid 0.076 mM, 50% inhibition Homo sapiens
MK 886 0.037 mM, 50% inhibition Homo sapiens
N-(2-phenylethyl)-indomethacin amide 0.098 mM, 50% inhibition Homo sapiens
N-(3-pyridyl)-indomethacin amide 0.1 mM, 50% inhibition Homo sapiens
niflumic acid 0.058 mM, 50% inhibition Homo sapiens
nimesulide 0.051 mM, 50% inhibition Homo sapiens
NS 398 0.064 mM, 50% inhibition Homo sapiens
resveratrol 0.054 mM, 50% inhibition Homo sapiens
rosiglitazone 0.026 mM, 50% inhibition Homo sapiens
sulindac 0.041 mM, 50% inhibition Homo sapiens
sulindac sulfide 0.018 mM, 50% inhibition Homo sapiens
sulindac sulfone 0.038 mM, 50% inhibition Homo sapiens
troglitazone 0.34 mM, 50% inhibition Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ Homo sapiens
-
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant 15-PGDH Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
-
Homo sapiens (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
r

Synonyms

Synonyms Comment Organism
NAD+-dependent 15-PGDH
-
Homo sapiens