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Literature summary for 1.1.1.141 extracted from

  • Tai, H.H.; Ensor, C.M.; Zhou, H.; Yan, F.
    Structure and function of human NAD+-linked 15-hydroxyprostaglandin dehydrogenase (2002), Adv. Exp. Med. Biol., 507, 245-250.
    View publication on PubMed
Search for more literature for 1.1.1.141

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Protein Variants

Protein Variants Comment Organism
C152A similar activity as wild-type Homo sapiens
C152F no activity Homo sapiens
C182A no activity Homo sapiens
C182F no activity Homo sapiens
C42A similar activity as wild-type Homo sapiens
C45F similar activity as wild-type Homo sapiens
C63A similar activity as wild-type Homo sapiens
C63F 10% of wild-type activity Homo sapiens
D64E no activity Homo sapiens
D64K low activity Homo sapiens
D64N similar activity as wild type Homo sapiens
D86E similar activity as wild type Homo sapiens
D86N similar activity as wild type Homo sapiens
L155L no activity Homo sapiens
L155Q no activity Homo sapiens
additional information C-terminal truncation decreases activity Homo sapiens
S138A no activity Homo sapiens
T188A no activity Homo sapiens
T188S substantial activity, lower than wild-type Homo sapiens
T188Y no activity Homo sapiens
Y151A no activity Homo sapiens
Y151F no activity Homo sapiens
Y151S no activity Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0039
-
 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate
-
 Homo sapiens
0.046
-
 NAD+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ Homo sapiens
-
 (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
-
 Homo sapiens (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?

Synonyms

Synonyms Comment Organism
15-PGDH
-
 Homo sapiens