Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.141 extracted from

  • Jarabak, J.
    Polycyclic aromatic hydrocarbon quinones may be either substrates for or irreversible inhibitors of the human placental NAD-linked 15-hydroxyprostaglandin dehydrogenase (1992), Arch. Biochem. Biophys., 292, 239-243.
    View publication on PubMed
Search for more literature for 1.1.1.141

Inhibitors

Inhibitors Comment Organism Structure
1,2-naphthoquinone 0.0002 mM, time dependent inactivation, 1 mM glutathione or 40% glycerol protect from inactivation; inactivation, glutathione protects Homo sapiens
2-methyl-1,4-naphthoquinone 0.02 mM, time dependent inactivation Homo sapiens
4,5-benzo[a]pyrenequinone 0.0002 mM, time dependent inactivation Homo sapiens
7,8-benzo[a]pyrenequinone 0.0002 mM, time dependent inactivation, 40% glycerol protects from inactivation; inactivation, glutathione protects Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ Homo sapiens first step in prostaglandin catabolism (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
7.79
-
 purified native enzyme Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ first step in prostaglandin catabolism Homo sapiens (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ i.e. 15-hydroxyprostaglandin or (15S)-PGE2 Homo sapiens (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?
5,6-chrysenequinone + NADH
-
 Homo sapiens ?
-
 ?
5,6-chrysenequinone + NADH formation of potentially hazardous semiquinones, reaction mechanism, overview Homo sapiens ? + H2O2
-
 ?
9,10-phenanthrenequinone + NADH
-
 Homo sapiens ?
-
 ?
9,10-phenanthrenequinone + NADH formation of potentially hazardous semiquinones, reaction mechanism, overview Homo sapiens ? + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
NAD+-linked 15-hydroxyprostaglandin dehydrogenase
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Homo sapiens