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Literature summary for 1.1.1.141 extracted from

  • Jung, A.; Schlegel, W.; Jackisch, R.; Friedrich, E.J.; Wendel, A.; Ruckrich, M.F.
    15-Hydroxyprostaglandin dehydrogenase from human placenta. 1. Isolation and characterization (1975), Hoppe-Seyler's Z. Physiol. Chem., 356, 787-798.
    View publication on PubMed

General Stability

General Stability Organism
glycerol, 50%, stabilizes Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
ethanol slight inhibition Homo sapiens
glycerol slight inhibition Homo sapiens
NADH
-
Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
32000
-
gel filtration in the presence of mercaptoethanol Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2
-
-
Homo sapiens

Storage Stability

Storage Stability Organism
-20°C, 50% glycerol, 10 mM 2-mercaptoethanol, stable for at least 1 year Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
-
Homo sapiens (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
?
11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+
-
Homo sapiens 11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH
-
?
prostaglandin F2alpha + NAD+
-
Homo sapiens 15-ketoprostaglandin F2alpha + NADH + H+
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9.5
-
-
Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
6 10 strong increase in activity between pH 8.0 and 9.5, sharp decrease above Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens