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Literature summary for 1.1.1.141 extracted from

  • Braithwaite, S.S.; Jabarak, J.
    Studies on a 15-hydroxyprostaglandin dehydrogenase from human placenta. Purification and partial characterization (1975), J. Biol. Chem., 250, 2315-2318.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Thionicotinamide adenine dinucleotide can replace NAD+ Homo sapiens
Thionicotinamide adenine dinucleotide 5-33% of the activity with NAD+, depending on substrate Homo sapiens

General Stability

General Stability Organism
glycerol, 50%, stabilizes Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
42000
-
1 * 42000, SDS-PAGE Homo sapiens
51500
-
gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.765
-
-
Homo sapiens

Storage Stability

Storage Stability Organism
-20°C, 50% glycerol, 2 months, 8% loss of activity Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ i.e. prostaglandin E1 Homo sapiens (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ i.e. 15-ketoprostaglandin E1 r
11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+ specific for NAD+ Homo sapiens 11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH
-
?
prostaglandin A1 + NAD+
-
Homo sapiens 15-ketoprostaglandin A1 + NADH + H+
-
?
prostaglandin F2alpha + NAD+ specific for NAD+ Homo sapiens 15-ketoprostaglandin F2alpha + NADH + H+
-
?

Subunits

Subunits Comment Organism
monomer 1 * 42000, SDS-PAGE Homo sapiens

Cofactor

Cofactor Comment Organism Structure
additional information
-
Homo sapiens
NAD+ specific for NAD+ Homo sapiens
NADH
-
Homo sapiens