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Literature summary for 1.1.1.14 extracted from
- Sorbitol can fuel mouse sperm motility and protein tyrosine phosphorylation via sorbitol dehydrogenase (2009), Biol. Reprod., 80, 124-133.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| additional information | SORD is associated with mitochondria and near the plasma membrane of the sperm flagellum, immunohistochemic analysis, overview | Mus musculus | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 39000 | - |
x * 39000, SDS-PAGE | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-sorbitol + NAD+ | Mus musculus | - |
D-fructose + NADH + H+ | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
CD1 mice | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cauda epididymidis | - |
Mus musculus | - |
| additional information | sorbitol can substitute for glucose or fructose in capacitating media | Mus musculus | - |
| sperm | SORD is present along the entire length of sperm flagellum, but does not show the same distribution pattern as alpha-tubulin. Sord mRNA and SORD protein expression is up-regulated during late spermiogenesis | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-sorbitol + NAD+ | - |
Mus musculus | D-fructose + NADH + H+ | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 39000, SDS-PAGE | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| sorbitol dehydrogenase | - |
Mus musculus |
| SORD | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | sorbitol dehydrogenase can convert sorbitol to fructose, which can then be metabolized via the glycolytic pathway in sperm to make ATP. Sorbitol can serve as an alternative energy source for sperm motility and protein tyrosine phosphorylation | Mus musculus |
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Release 2023.1 (January 2023)
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