Literature summary for 1.1.1.14 extracted from

Pauly, T.A.; Ekstrom, J.L.; Beebe, D.A.; Chrunyk, B.; Cunningham, D.; Griffor, M.; Kamath, A.; Lee, S.E.; Madura, R.; McGuire, D.; Subashi, T.; Wasilko, D.; Watts, P.; Mylari, B.L.; Oates, P.J.; Adams, P.D.; Rath, V.L.
X-ray crystallographic and kinetic studies of human sorbitol dehydrogenase (2003), Structure, 11, 1071-1085.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
purified enzyme alone, and in complex with NAD+, or with NADH and inhibitor SDI-158, X-ray diffraction structure determination and analysis at 1.9-2.0 A resolution, modelling	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
2-hydroxymethyl-4-(4-N,N-dimethylaminosulfonyl-1-piperazino)pyrimidine	i.e. SDI-158 or CP-166,572	Homo sapiens
2-methyl-4-(4-N,N-dimethylaminosulfonyl-1-piperazino)pyrimidine	i.e. SDI-157	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zn2+	the catalytic zinc is coordinated with residues His69, Cys44, Glu70, and a water molecule	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
D-sorbitol + NAD+	Homo sapiens	part of the polyol pathway that interconverts glucose and fructose	L-sorbose + NADH + H+	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q00796	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-sorbitol + NAD+	-	Homo sapiens	L-sorbose + NADH + H+	-	?
D-sorbitol + NAD+	part of the polyol pathway that interconverts glucose and fructose	Homo sapiens	L-sorbose + NADH + H+	-	?

Subunits

Subunits	Comment	Organism
tetramer	4 identical, catalytically active subunits, crystal structure	Homo sapiens

Synonyms

Synonyms	Comment	Organism
SDH	-	Homo sapiens
sorbitol dehydrogenase	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Homo sapiens

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Release 2023.1 (January 2023)