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Literature summary for 1.1.1.14 extracted from
- Purification and characterization of NAD+-dependent sorbitol dehydrogenase from Japanese pear fruit (2000), Phytochemistry, 54, 567-572.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| ZnSO4 | reverses cysteine inhibition | Pyrus pyrifolia |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| cysteine | inhibits fructose reduction at pH 9.0, stimulates at pH 7.4 | Pyrus pyrifolia | |
| HgCl2 | - |
Pyrus pyrifolia | |
| MgCl2 | - |
Pyrus pyrifolia | |
| MnSO4 | - |
Pyrus pyrifolia | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Pyrus pyrifolia | - |
japanese pear | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Pyrus pyrifolia |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| fruit | - |
Pyrus pyrifolia | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 55 | - |
- |
Pyrus pyrifolia |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-ribitol + NAD+ | - |
Pyrus pyrifolia | ? | - |
? | |
| D-sorbitol + NAD+ | - |
Pyrus pyrifolia | D-fructose + NADH + H+ | - |
? | |
| D-xylitol + NAD+ | - |
Pyrus pyrifolia | ? | - |
? | |
| erythritol + NAD+ | low activity | Pyrus pyrifolia | ? | - |
? | |
| ethanol + NAD+ | low activity | Pyrus pyrifolia | acetaldehyde + NADH | - |
? | |
| L-arabitol + NAD+ | low activity | Pyrus pyrifolia | ? | - |
? | |
| L-iditol + NAD+ | - |
Pyrus pyrifolia | ? | - |
? | |
| L-threitol + NAD+ | - |
Pyrus pyrifolia | ? | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
D-fructose reduction | Pyrus pyrifolia |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5 | 7.5 | less than 20% of maximal activity below pH 5, less than 80% above pH 7.5, fructose reduction | Pyrus pyrifolia |
| 7.5 | 9 | less than 20% of maximal activity below pH 7.5, 100% at pH 9.0, sorbitol oxidation | Pyrus pyrifolia |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Pyrus pyrifolia | |
| NADH | - |
Pyrus pyrifolia | |
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