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Literature summary for 1.1.1.14 extracted from
- Complete protection by alpha-crystallin of lens sorbitol dehydrogenase undergoing thermal stress (2000), J. Biol. Chem., 275, 32559-32565.
General Stability
| General Stability | Organism |
|---|---|
| alpha-crystallin stabilizes | Bos taurus |
| bovine serum albumin stabilizes | Bos taurus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| lens | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-fructose + NADH + H+ | - |
Bos taurus | D-sorbitol + NAD+ | - |
? |  |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 18 | - |
50% loss of activity after 40 min, alpha-crystallin protects fully against activity loss | Bos taurus |
| 45 | - |
50% loss of activity after 20 min, alpha-crystallin protects fully against activity loss | Bos taurus |
| 55 | - |
50% loss of activity after 10 min, alpha-crystallin protects fully against activity loss | Bos taurus |
| 60 | - |
50% loss of activity after 5 min, alpha-crystallin reduces activity loss by 50% | Bos taurus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Bos taurus | |
| NADH | - |
Bos taurus | |
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Release 2023.1 (January 2023)
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