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Literature summary for 1.1.1.14 extracted from
- Human sorbitol dehydrogenase - a secondary alcohol dehydrogenase with distinct pathophysiological roles, pH dependent kinetic studies (1996), Adv. Exp. Med. Biol., , 383-393.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1 | - |
D-xylulose | - |
Homo sapiens |  |
| 25 | - |
L-erythrulose | - |
Homo sapiens | |
| 34 | - |
D-ribulose | - |
Homo sapiens | |
| 140 | - |
D-fructose | - |
Homo sapiens | |
| 800 | - |
L-sorbose | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-fructose + NADH + H+ | - |
Homo sapiens | D-sorbitol + NAD+ | - |
? | |
| D-psicose + NADH | - |
Homo sapiens | ? | - |
? | |
| D-ribulose + NADH | - |
Homo sapiens | ? | - |
? | |
| D-sorbitol + NAD+ | - |
Homo sapiens | D-fructose + NADH + H+ | - |
? | |
| D-sorbose + NADH | low activity | Homo sapiens | ? | - |
? | |
| D-tagatose + NADH | - |
Homo sapiens | D-galactitol + NAD+ | - |
? | |
| D-xylulose + NADH | - |
Homo sapiens | ? | - |
? | |
| L-erythrulose + NADH | - |
Homo sapiens | ? | - |
? | |
| L-sorbose + NADH | - |
Homo sapiens | ? | - |
? | |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 6 | - |
loses zinc at lower pH | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Homo sapiens | |
| NADH | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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