Literature summary for 1.1.1.14 extracted from

Lindstad, R.I.; Hermansen, L.F.; McKinley-McKee, J.S.
Inhibition and activation studies on sheep liver sorbitol dehydrogenase (1994), Eur. J. Biochem., 221, 847-854.

Activating Compound

Activating Compound	Comment	Organism
(R)-(-)-2-octanol	at pH 9.9	Ovis aries
(S)-(+)-2-octanol	at pH 9.9	Ovis aries
1-Hexanol	-	Ovis aries
1-Octanol	-	Ovis aries
2,2,2-tribromoethanol	-	Ovis aries
2,2,2-trichloroethanol	-	Ovis aries
2,2,2-Trifluoroethanol	-	Ovis aries
2-monobromoethanol	-	Ovis aries
2-monochloroethanol	-	Ovis aries
2-monofluoroethanol	-	Ovis aries
NaBr	-	Ovis aries
NaCl	-	Ovis aries
NaI	-	Ovis aries
SDS	-	Ovis aries
sodium taurodeoxycholate	-	Ovis aries

Inhibitors

Inhibitors	Comment	Organism
(2S)-1-(3-thio-2-methylpropionyl)-L-proline	-	Ovis aries
1,10-phenanthroline	-	Ovis aries
1,2,3,4,5,6-cyclohexanehexolphosphoric acid	at pH 9.9	Ovis aries
1,2-dithioethane	-	Ovis aries
1,7-phenanthroline	-	Ovis aries
1-thiobutane	-	Ovis aries
1-thioglycol	-	Ovis aries
1-thiosorbitol	-	Ovis aries
2,2'-dipyridyl	-	Ovis aries
2,3-Dithiopropanol	-	Ovis aries
2-hydroxybenzoic acid	at pH 9.9	Ovis aries
2-mercaptoethanol	-	Ovis aries
2-methypropanoic acid amide	at pH 9.9	Ovis aries
2-propylpentanoic acid	at pH 9.9	Ovis aries
2-thiobutane	-	Ovis aries
3,4-dihydroxyphenyl-1-hydroxyacetic acid	at pH 7.4	Ovis aries
3,4-dihydroxyphenyl-ethanediol	at pH 7.4	Ovis aries
3-hydroxy-4-methoxy-phenyl-1-hydroxy-acetic acid	at pH 7.4	Ovis aries
4,4'-dipyridyl	-	Ovis aries
4-hydroxy-3-methoxy-phenyl-1-hydroxy-acetic acid	at pH 7.4	Ovis aries
4-hydroxy-3-methoxy-phenylacetic acid	at pH 7.4	Ovis aries
4-hydroxy-3-methoxy-phenylethanediol	at pH 7.4	Ovis aries
4-hydroxy-3-methoxy-phenylethyl alcohol	at pH 7.4	Ovis aries
8-hydroxyquinoline	-	Ovis aries
acetic acid amide	at pH 9.9	Ovis aries
Alrestatin	-	Ovis aries
Berberine	-	Ovis aries
bis-diethylthiocarbamoyldisulfide	-	Ovis aries
butanedioic acid	at pH 9.9	Ovis aries
Cibacron Blue 3G-A	-	Ovis aries
cyanamide	at pH 9.9	Ovis aries
cysteamine	significant only at pH 9.9	Ovis aries
cysteine	-	Ovis aries
Decanoic acid	at pH 9.9	Ovis aries
Diethylthiocarbamate	at pH 9.9	Ovis aries
dithiothreitol	-	Ovis aries
DL-2-thiovaline	-	Ovis aries
Eriochrome Black T	-	Ovis aries
ethanedioic acid	at pH 9.9	Ovis aries
ICI 171071	-	Ovis aries
ICI 222155	-	Ovis aries
imidazole	-	Ovis aries
Isonicotinic acid hydrazide	-	Ovis aries
ponalrestat	-	Ovis aries
propanedioic acid	at pH 9.9	Ovis aries
pyrazole	-	Ovis aries
quercetin	at pH 7.4	Ovis aries
thioacetate	at pH 9.9	Ovis aries
thiocyanate	at pH 9.9	Ovis aries
Thiourea	at pH 9.9	Ovis aries
Tolrestat	-	Ovis aries
Urea	at pH 9.9	Ovis aries

Organism

Organism	UniProt	Comment	Textmining
Ovis aries	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Ovis aries	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-sorbitol + NAD+	-	Ovis aries	D-fructose + NADH + H+	-	?

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Ovis aries
NADH	-	Ovis aries