Literature summary for 1.1.1.132 extracted from

Beswick, L.; Dimitriou, E.; Ahmadipour, S.; Zafar, A.; Rejzek, M.; Reynisson, J.; Field, R.A.; Miller, G.J.
Inhibition of the GDP-D-mannose dehydrogenase from Pseudomonas aeruginosa using targeted sugar nucleotide probes (2020), ACS Chem. Biol., 15, 3086-3092 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
C6-amido-GDP-D-mannose	mixed mechanism of inhibition	Pseudomonas aeruginosa

Organism

Organism	UniProt	Comment	Textmining
Pseudomonas aeruginosa	P11759	-	-
Pseudomonas aeruginosa ATCC 15692	P11759	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GDP-D-mannose + 2 NAD+ + H2O	-	Pseudomonas aeruginosa	GDP-D-mannuronate + 2 NADH + 2 H+	-	?
GDP-D-mannose + 2 NAD+ + H2O	-	Pseudomonas aeruginosa ATCC 15692	GDP-D-mannuronate + 2 NADH + 2 H+	-	?

Synonyms

Synonyms	Comment	Organism
GDP-D-mannose dehydrogenase	-	Pseudomonas aeruginosa
GMD	-	Pseudomonas aeruginosa
guanosine diphosphate mannose dehydrogenase	-	Pseudomonas aeruginosa

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.112	-	pH and temperature not specified in the publication	Pseudomonas aeruginosa	C6-amido-GDP-D-mannose

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Release 2023.1 (January 2023)