Literature summary for 1.1.1.132 extracted from

Elloumi, N.; Moreau, B.; Aguiar, L.; Jaziri, N.; Sauvage, M.; Hulen, C.; Capmau, M.L.
Inhibitors of GDP-mannose dehydrogenase of Pseudomonas aeruginosa mucoid strains (1992), Eur. J. Med. Chem., 27, 149-154.

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Inhibitors

Inhibitors	Comment	Organism	Structure
5'-(3-hydroxypropyl)-amino-5'-deoxy-guanosine	only after preincubation with enzyme	Pseudomonas aeruginosa
5'-azido-5'-deoxy-guanosine	only after preincubation with enzyme	Pseudomonas aeruginosa
5'-azido-5'-deoxy-N2-2',3'-O-triacetylguanosine	only after preincubation with enzyme	Pseudomonas aeruginosa
5'[[[[(2'',3'',4'',6''-tetra-O-acetyl 6''-ethynyl)alpha-D-mannopyranosyl oxy]-carbonyl]amino]sulfonyl]-2',3'-isopropylidene N2-acetyl guanosine	GDP-analog, 0.1 mM, 60% inhibition	Pseudomonas aeruginosa
guanosine	slight inhibition only after preincubation with enzyme	Pseudomonas aeruginosa
additional information	strains which resist 0.005 mg/ml of tobramycin treated by 5'-(3-hydroxypropyl)-amino-5'-deoxy-guanosine, tetra-O-acetylmannopyranose and 5'[[[[(2'',3'',4'',6''-tetra-O-acetyl 6''-ethynyl)alpha-D-mannopyranosyl oxy]-carbonyl]amino]sulfonyl]-2',3'-isopropylidene N2-acetyl guanosine recover 20, 75 and 85% of their sensisivity towards tobramycin	Pseudomonas aeruginosa
N2-acetyl-2',3'-isopropylidene guanosine	only after preincubation with enzyme	Pseudomonas aeruginosa
N2-acetyl-5'-amino-5'-deoxy-2',3'-O-acetylguanosine	only after preincubation with enzyme	Pseudomonas aeruginosa
N2-acetyl-5'-amino-5'-deoxy-guanosine	only after preincubation with enzyme	Pseudomonas aeruginosa
N2-acetyl-guanosine	only after preincubation with enzyme	Pseudomonas aeruginosa
tetra-O-acetylmannopyranose	GDP-analog, 0.1 mM, 75% inhibition	Pseudomonas aeruginosa

Organism

Organism	UniProt	Comment	Textmining
Pseudomonas aeruginosa	-	A22 alg+, selected from mucoid strain IPA22	-

Purification (Commentary)

Purification (Comment)	Organism
protamine sulfate precipitation, gel exclusion, ion exchange chromatography	Pseudomonas aeruginosa

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GDP-mannose + NAD+ + H2O	-	Pseudomonas aeruginosa	GDP-mannuronate + NADH	-	?

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Pseudomonas aeruginosa

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Release 2023.1 (January 2023)