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Literature summary for 1.1.1.12 extracted from

  • Mahmud, A.; Hattori, K.; Hongwen, C.; Kitamoto, N.; Suzuki, T.; Nakamura, K.; Takamizawa, K.
    Xylitol production by NAD+-dependent xylitol dehydrogenase (xdhA)- and L-arabitol-4-dehydrogenase (ladA)-disrupted mutants of Aspergillus oryzae (2013), J. Biosci. Bioeng., 115, 353-359.
    View publication on PubMed
Search for more literature for 1.1.1.12

Cloned(Commentary)

Cloned (Comment) Organism
gene ladA Aspergillus oryzae

Protein Variants

Protein Variants Comment Organism
additional information construction of deletion mutants of ladA by homologous transformation, to generate mutants with decreased dehydrogenase activities and increased xylitol production. Gene pyrG is used as a selectable marker. Consumption of D-xylose for xdhA2-1 and ladA2-1 is similar to that of KBN616. Mutant ladA2-1 displays the reduced xylitol productivity Aspergillus oryzae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-arabinitol + NAD+ Aspergillus oryzae
-
 L-xylulose + NADH + H+
-
 ?
L-arabinitol + NAD+ Aspergillus oryzae P5
-
 L-xylulose + NADH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Aspergillus oryzae Q763T4 a DELTApyrG strain developed from strain KBN616
-
Aspergillus oryzae P5 Q763T4 a DELTApyrG strain developed from strain KBN616
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-arabinitol + NAD+
-
 Aspergillus oryzae L-xylulose + NADH + H+
-
 ?
L-arabinitol + NAD+
-
 Aspergillus oryzae P5 L-xylulose + NADH + H+
-
 ?

Synonyms

Synonyms Comment Organism
L-arabitol dehydrogenase
-
 Aspergillus oryzae
LADA
-
 Aspergillus oryzae

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Aspergillus oryzae

General Information

General Information Comment Organism
additional information xylitol production of wild-type and mutant strains, overview Aspergillus oryzae