Monkey liver indanol dehydrogenase. Purification, properties, and kinetic mechanism

Hara, A.; Mouri, K.; Nakagawa, M.; Nakamura, M.; Nakayama, T.; Matsuura, K.; Saweda, H.; J. Biochem. 106, 126-132 (1989)

Data extracted from this reference:

Inhibitors

Commentary

Organism

Structure

1,10-phenanthroline

competitive inhibition vs. indanol

Macaca fuscata

2,2'-bipyridine

competitive inhibition vs. indanol

Macaca fuscata

4,4'-Bipyridine

competitive inhibition vs. indanol

Macaca fuscata

8-hydroxyquinoline

competitive inhibition vs. indanol

Macaca fuscata

Cibacron blue

noncompetitive inhibition vs. indanol

Macaca fuscata

Hexestrol

competitive inhibition vs. indanol

Macaca fuscata

Medroxyprogesterone acetate

competitive inhibition vs. indanol

Macaca fuscata

progesterone

competitive inhibition vs. indanol

Macaca fuscata

Reaction

Commentary

Organism

Reaction ID

indan-1-ol + NAD(P)+ = indanone + NAD(P)H + H+

A-stereospecific enzyme, ping-pong mechanism

Macaca fuscata

Substrates

Commentary Substrates

Literature (Substrates)

Organism

Products

Commentary (Products)

Literature (Products)

Organism (Products)

Reversibility

Substrate Product ID

1,2,3,4-tetrahydro-1-naphthol + NAD(P)+

-

285758

Macaca fuscata

1,2,3,4-tetrahydro-1-naphthone + NAD(P)H

-

285758

Macaca fuscata

?

1-acenaphthenol + NAD(P)+

-

285758

Macaca fuscata

1-acenaphthenone + NAD(P)H

-

285758

Macaca fuscata

?

2,3-butanedione + NAD(P)H

-

285758

Macaca fuscata

2,3-butanediol + NAD(P)+

-

285758

Macaca fuscata

?

2,3-heptanedione + NAD(P)H

-

285758

Macaca fuscata

2,3-heptanediol + NAD(P)+

-

285758

Macaca fuscata

?

2-nitrobenzaldehyde + NAD(P)H

-

285758

Macaca fuscata

2-nitrobenzyl alcohol + NAD(P)+

-

285758

Macaca fuscata

?

3-nitrobenzaldehyde + NAD(P)H

-

285758

Macaca fuscata

3-nitrobenzyl alcohol + NAD(P)+

-

285758

Macaca fuscata

?

4-nitrobenzaldehyde + NAD(P)H

-

285758

Macaca fuscata

4-nitrobenzyl alcohol + NAD(P)+

-

285758

Macaca fuscata

?

benzene dihydrodiol + NAD(P)+

-

285758

Macaca fuscata

o-benzoquinone + NAD(P)H

-

285758

Macaca fuscata

?

camphorquinone + NAD(P)H + H+

-

285758

Macaca fuscata

camphane-2,3-diol + NAD(P)+

-

285758

Macaca fuscata

?

cyclohex-2-en-1-ol + NAD(P)+

-

285758

Macaca fuscata

cyclohex-2-en-1-one + NAD(P)H

-

285758

Macaca fuscata

?

indan-(RS)-1-ol + NAD(P)+

-

285758

Macaca fuscata

indan-1-one + NAD(P)H

-

285758

Macaca fuscata

?

indan-(S)-1-ol + NAD(P)+

-

285758

Macaca fuscata

indan-1-one + NAD(P)H

-

285758

Macaca fuscata

?

indan-2-ol + NAD(P)+

-

285758

Macaca fuscata

indan-2-one + NAD(P)H

-

285758

Macaca fuscata

?

trans-1,2-dihydroxy-1,2-dihydronaphthalene + NAD(P)+

-

285758

Macaca fuscata

1,2-naphthoquinone + NAD(P)H

-

285758

Macaca fuscata

?

Cofactor

Commentary

Organism

Structure

NAD+

-

Macaca fuscata

NADP+

5 times higher dehydrogenase rates compared to NAD+

Macaca fuscata

Cofactor

Commentary

Organism

Structure

NAD+

-

Macaca fuscata

NADP+

5 times higher dehydrogenase rates compared to NAD+

Macaca fuscata

Inhibitors

Commentary

Organism

Structure

1,10-phenanthroline

competitive inhibition vs. indanol

Macaca fuscata

2,2'-bipyridine

competitive inhibition vs. indanol

Macaca fuscata

4,4'-Bipyridine

competitive inhibition vs. indanol

Macaca fuscata

8-hydroxyquinoline

competitive inhibition vs. indanol

Macaca fuscata

Cibacron blue

noncompetitive inhibition vs. indanol

Macaca fuscata

Hexestrol

competitive inhibition vs. indanol

Macaca fuscata

Medroxyprogesterone acetate

competitive inhibition vs. indanol

Macaca fuscata

progesterone

competitive inhibition vs. indanol

Macaca fuscata

Substrates

Commentary Substrates

Literature (Substrates)

Organism

Products

Commentary (Products)

Literature (Products)

Organism (Products)

Reversibility

ID

1,2,3,4-tetrahydro-1-naphthol + NAD(P)+

-

285758

Macaca fuscata

1,2,3,4-tetrahydro-1-naphthone + NAD(P)H

-

285758

Macaca fuscata

?

1-acenaphthenol + NAD(P)+

-

285758

Macaca fuscata

1-acenaphthenone + NAD(P)H

-

285758

Macaca fuscata

?

2,3-butanedione + NAD(P)H

-

285758

Macaca fuscata

2,3-butanediol + NAD(P)+

-

285758

Macaca fuscata

?

2,3-heptanedione + NAD(P)H

-

285758

Macaca fuscata

2,3-heptanediol + NAD(P)+

-

285758

Macaca fuscata

?

2-nitrobenzaldehyde + NAD(P)H

-

285758

Macaca fuscata

2-nitrobenzyl alcohol + NAD(P)+

-

285758

Macaca fuscata

?

3-nitrobenzaldehyde + NAD(P)H

-

285758

Macaca fuscata

3-nitrobenzyl alcohol + NAD(P)+

-

285758

Macaca fuscata

?

4-nitrobenzaldehyde + NAD(P)H

-

285758

Macaca fuscata

4-nitrobenzyl alcohol + NAD(P)+

-

285758

Macaca fuscata

?

benzene dihydrodiol + NAD(P)+

-

285758

Macaca fuscata

o-benzoquinone + NAD(P)H

-

285758

Macaca fuscata

?

camphorquinone + NAD(P)H + H+

-

285758

Macaca fuscata

camphane-2,3-diol + NAD(P)+

-

285758

Macaca fuscata

?

cyclohex-2-en-1-ol + NAD(P)+

-

285758

Macaca fuscata

cyclohex-2-en-1-one + NAD(P)H

-

285758

Macaca fuscata

?

indan-(RS)-1-ol + NAD(P)+

-

285758

Macaca fuscata

indan-1-one + NAD(P)H

-

285758

Macaca fuscata

?

indan-(S)-1-ol + NAD(P)+

-

285758

Macaca fuscata

indan-1-one + NAD(P)H

-

285758

Macaca fuscata

?

indan-2-ol + NAD(P)+

-

285758

Macaca fuscata

indan-2-one + NAD(P)H

-

285758

Macaca fuscata

?

trans-1,2-dihydroxy-1,2-dihydronaphthalene + NAD(P)+

-

285758

Macaca fuscata

1,2-naphthoquinone + NAD(P)H

-

285758

Macaca fuscata

?

No.

1st author

Pub Med

title

organims

journal

volume

pages

year

Activating Compound

Application

Cloned(Commentary)

Crystallization (Commentary)

Engineering

General Stability

Inhibitors

KM Value [mM]

Localization

Metals/Ions

Molecular Weight [Da]

Natural Substrates/ Products (Substrates)

Organic Solvent Stability

Organism

Oxidation Stability

Posttranslational Modification

Purification (Commentary)

Reaction

Renatured (Commentary)

Source Tissue

Specific Activity [micromol/min/mg]

Storage Stability

Substrates and Products (Substrate)

Subunits

Synonyms

Temperature Optimum [°C]

Temperature Range [°C]

Temperature Stability [°C]

Turnover Number [1/s]

pH Optimum

pH Range

pH Stability

Cofactor

Ki Value [mM]

pI Value

IC50 Value

Activating Compound (protein specific)

Application (protein specific)

Cloned(Commentary) (protein specific)

Cofactor (protein specific)

Crystallization (Commentary) (protein specific)

Engineering (protein specific)

General Stability (protein specific)

IC50 Value (protein specific)

Inhibitors (protein specific)

Ki Value [mM] (protein specific)

KM Value [mM] (protein specific)

Localization (protein specific)

Metals/Ions (protein specific)

Molecular Weight [Da] (protein specific)

Natural Substrates/ Products (Substrates) (protein specific)

Organic Solvent Stability (protein specific)

Oxidation Stability (protein specific)

Posttranslational Modification (protein specific)

Purification (Commentary) (protein specific)

Renatured (Commentary) (protein specific)

Source Tissue (protein specific)

Specific Activity [micromol/min/mg] (protein specific)

Storage Stability (protein specific)

Substrates and Products (Substrate) (protein specific)

Subunits (protein specific)

Temperature Optimum [°C] (protein specific)

Temperature Range [°C] (protein specific)

Temperature Stability [°C] (protein specific)

Turnover Number [1/s] (protein specific)

pH Optimum (protein specific)

pH Range (protein specific)

pH Stability (protein specific)

pI Value (protein specific)

Expression

General Information

General Information (protein specific)

Expression (protein specific)

KCat/KM [mM/s]

KCat/KM [mM/s] (protein specific)

285758

Hara

Monkey liver indanol dehydroge ...

Macaca fuscata

J. Biochem.

106

126-132

1989

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8

-

1

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2

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2

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1

1

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7

1

1

14

1

-

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1

1

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1

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1

2

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2

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8

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1

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7

1

1

14

1

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1

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1

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-

285759

Hara

3(20)alpha-hydroxysteroi dehyd ...

Macaca fuscata

J. Biochem.

106

900-903

1989

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2

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3

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18

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1

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2

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3

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18

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1

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285760

Hara

Isolation of multiple forms of ...

Oryctolagus cuniculus

Arch. Biochem. Biophys.

249

225-236

1986

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8

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1

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6

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2

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7

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29

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8

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6

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7

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29

-

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1

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285761

Kulkarni

Human placental indanol dehydr ...

Homo sapiens

Xenobiotica

15

513-519

1985

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2

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2

6

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1

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2

6

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1

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1

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285762

Billings

The dehydrogenation of 1-indan ...

Bos taurus

J. Biol. Chem.

246

3512-3517

1971

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8

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