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Literature summary for 1.1.1.108 extracted from

  • Vandecasteele, J-P.
    Enzymatic synthesis of L-carnitine by reduction of an achiral precursor: the problem of reduced nicotinamide adenine dinucleotide recycling (1980), Appl. Environ. Microbiol., 39, 327-334.
    View publication on PubMedView publication on EuropePMC
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KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.022
-
 NADH
-
 Pseudomonas aeruginosa
1.25
-
 3-dehydrocarnitine
-
 Pseudomonas putida
1.3
-
 3-dehydrocarnitine
-
 Pseudomonas aeruginosa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(R)-3-hydroxy-4-trimethylaminobutyrate + NAD+ Pseudomonas aeruginosa
-
 3-dehydrocarnitine + NADH + H+
-
 r
(R)-3-hydroxy-4-trimethylaminobutyrate + NAD+ Pseudomonas putida
-
 3-dehydrocarnitine + NADH + H+
-
 r

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
-
-
-
Pseudomonas putida
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2
-
 L-carnitine dehydrogenase activity in crude extracts Pseudomonas putida

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-3-hydroxy-4-trimethylaminobutyrate + NAD+
-
 Pseudomonas aeruginosa 3-dehydrocarnitine + NADH + H+
-
 r
(R)-3-hydroxy-4-trimethylaminobutyrate + NAD+
-
 Pseudomonas putida 3-dehydrocarnitine + NADH + H+
-
 r
carnitine + NAD+
-
 Pseudomonas aeruginosa 3-dehydrocarnitine + NADH + H+
-
 r
carnitine + NAD+
-
 Pseudomonas putida 3-dehydrocarnitine + NADH + H+
-
 r

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Pseudomonas aeruginosa
NAD+
-
 Pseudomonas putida