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Literature summary for 1.1.1.102 extracted from

  • Beeler, T.; Bacikova, D.; Gable, K.; Hopkins, L.; Johnson, C.; Slife, H.; Dunn, T.
    The Saccharomyces cerevisiae TSC10/BR265w gene encoding 3-ketosphinganine reductase is identified in a screen for temperature-sensitive suppressors of the Ca2+-sensitive csg2delta mutant (1998), J. Biol. Chem., 273, 30688-30694.
    View publication on PubMed
Search for more literature for 1.1.1.102

Activating Compound

Activating Compound Comment Organism Structure
tergitol 0.2%, 10fold activation of 2-amino-1-hydroxyoctadecane-3-one reduction Saccharomyces cerevisiae

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli, Myc-His-tagged enzyme Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-amino-1-hydroxyoctadecan-3-one + NADPH Saccharomyces cerevisiae
-
 2-amino-1,3-dihydroxyoctadecane + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant Myc-His-tagged enzyme, Ni-NTA agarose Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-amino-1-hydroxyoctadecan-3-one + NADPH
-
 Saccharomyces cerevisiae (2S,3R)-2-aminooctadecane-1,3-diol + NADP+
-
 ?
2-amino-1-hydroxyoctadecan-3-one + NADPH
-
 Saccharomyces cerevisiae 2-amino-1,3-dihydroxyoctadecane + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
3-ketosphinganine reductase
-
 Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Saccharomyces cerevisiae