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Literature summary for 1.1.1.101 extracted from

  • Minskoff, S.A.; Racenis, P.V.; Granger, J.; Larkins, L.; Hajra, A.K.; Greenberg, M.L.
    Regulation of phosphatidic acid biosynthetic enzymes in Saccharomyces cerevisiae (1994), J. Lipid Res., 35, 2254-2262.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
dihydroxyacetone activation, used as carbon source in wild type cell cultures, greater activity compared to activity in glucose-grown cells Saccharomyces cerevisiae
ethanol activation, used as nonfermentable carbon source in wild type and tpa1 mutant cell cultures, greater activity compared to activity in glucose-grown cells Saccharomyces cerevisiae
glycerol activation, used as nonfermentable carbon source in wild type cell cultures, greater activity compared to activity in glucose-grown cells Saccharomyces cerevisiae
glycerol/ethanol activation, used as nonfermentable carbon source in wild type cell cultures, greater activity compared to activity in glucose-grown cells Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyldihydroxyacetone phosphate + NADPH Saccharomyces cerevisiae acyldihydroxyacetone phosphate pathway 1-acyl-sn-glycerol 3-phosphate + NADP+
-
?
acyldihydroxyacetone phosphate + NADPH Saccharomyces cerevisiae reaction in non-ether lipids biosynthesis 1-acyl-sn-glycerol 3-phosphate + NADP+
-
?
acyldihydroxyacetone phosphate + NADPH Saccharomyces cerevisiae tpa1 acyldihydroxyacetone phosphate pathway 1-acyl-sn-glycerol 3-phosphate + NADP+
-
?
acyldihydroxyacetone phosphate + NADPH Saccharomyces cerevisiae tpa1 reaction in non-ether lipids biosynthesis 1-acyl-sn-glycerol 3-phosphate + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
tpa1 mutant strain
-
Saccharomyces cerevisiae
-
wild-type strain
-
Saccharomyces cerevisiae tpa1
-
tpa1 mutant strain
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.00393
-
glucose grown cells Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyldihydroxyacetone phosphate + NADPH
-
Saccharomyces cerevisiae 1-acyl-sn-glycerol 3-phosphate + NADP+ i.e. lysophosphatidic acid ?
acyldihydroxyacetone phosphate + NADPH acyldihydroxyacetone phosphate pathway Saccharomyces cerevisiae 1-acyl-sn-glycerol 3-phosphate + NADP+
-
?
acyldihydroxyacetone phosphate + NADPH reaction in non-ether lipids biosynthesis Saccharomyces cerevisiae 1-acyl-sn-glycerol 3-phosphate + NADP+
-
?
acyldihydroxyacetone phosphate + NADPH
-
Saccharomyces cerevisiae tpa1 1-acyl-sn-glycerol 3-phosphate + NADP+ i.e. lysophosphatidic acid ?
acyldihydroxyacetone phosphate + NADPH acyldihydroxyacetone phosphate pathway Saccharomyces cerevisiae tpa1 1-acyl-sn-glycerol 3-phosphate + NADP+
-
?
acyldihydroxyacetone phosphate + NADPH reaction in non-ether lipids biosynthesis Saccharomyces cerevisiae tpa1 1-acyl-sn-glycerol 3-phosphate + NADP+
-
?
hexadecyldihydroxyacetone phosphate + NADPH
-
Saccharomyces cerevisiae 1-hexadecyl-sn-glycerol 3-phosphate + NADP+
-
?
hexadecyldihydroxyacetone phosphate + NADPH
-
Saccharomyces cerevisiae tpa1 1-hexadecyl-sn-glycerol 3-phosphate + NADP+
-
?

Cofactor

Cofactor Comment Organism Structure
NADPH hydrogen from B-side of nicotinamide ring is transferred to reduce keto substrates Saccharomyces cerevisiae