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Literature summary for 1.1.1.100 extracted from
- Inhibitory effects on bacterial growth and b-ketoacyl-ACP reductase by different species of maple leaf extracts and tannic acid (2009), Phytother. Res., 24, 535-541.
No PubMed abstract available
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | FabG is the antibacteria target of maple leaf extracts and tannic acid, and both reversible and irreversible inhibitions of FabG are important for the antibacterial effect | Salmonella enterica subsp. enterica serovar Typhimurium |
| drug development | FabG is the antibacteria target of maple leaf extracts and tannic acid, and both reversible and irreversible inhibitions of FabG are important for the antibacterial effect | Staphylococcus aureus |
| drug development | FabG is the antibacteria target of maple leaf extracts and tannic acid, and both reversible and irreversible inhibitions of FabG are important for the antibacterial effect | Escherichia coli |
| drug development | FabG is the antibacteria target of maple leaf extracts and tannic acid, and both reversible and irreversible inhibitions of FabG are important for the antibacterial effect | Enterobacter cloacae |
| drug development | FabG is the antibacteria target of maple leaf extracts and tannic acid, and both reversible and irreversible inhibitions of FabG are important for the antibacterial effect | Klebsiella aerogenes |
| drug development | FabG is the antibacteria target of maple leaf extracts and tannic acid, and both reversible and irreversible inhibitions of FabG are important for the antibacterial effect | Pseudomonas aeruginosa |
| drug development | FabG is the antibacteria target of maple leaf extracts and tannic acid, and both reversible and irreversible inhibitions of FabG are important for the antibacterial effect | Acinetobacter calcoaceticus |
| drug development | FabG is the antibacteria target of maple leaf extracts and tannic acid, and both reversible and irreversible inhibitions of FabG are important for the antibacterial effect | Serratia marcescens |
| drug development | FabG is the antibacteria target of maple leaf extracts and tannic acid, and both reversible and irreversible inhibitions of FabG are important for the antibacterial effect | Proteus vulgaris |
| drug development | FabG is the antibacteria target of maple leaf extracts and tannic acid, and both reversible and irreversible inhibitions of FabG are important for the antibacterial effect | Klebsiella pneumoniae |
| drug development | FabG is the antibacteria target of maple leaf extracts and tannic acid, and both reversible and irreversible inhibitions of FabG are important for the antibacterial effect | Staphylococcus epidermidis |
| drug development | FabG is the antibacteria target of maple leaf extracts and tannic acid, and both reversible and irreversible inhibitions of FabG are important for the antibacterial effect | Salmonella enterica subsp. enterica serovar Typhi |
| drug development | FabG is the antibacteria target of maple leaf extracts and tannic acid, and both reversible and irreversible inhibitions of FabG are important for the antibacterial effect | Shigella sonnei |
| drug development | FabG is the antibacteria target of maple leaf extracts and tannic acid, and both reversible and irreversible inhibitions of FabG are important for the antibacterial effect | Shigella dysenteriae |
| drug development | FabG is the antibacteria target of maple leaf extracts and tannic acid, and both reversible and irreversible inhibitions of FabG are important for the antibacterial effect | Shigella flexneri |
| drug development | FabG is the antibacteria target of maple leaf extracts and tannic acid, and both reversible and irreversible inhibitions of FabG are important for the antibacterial effect | Enterococcus sp. |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| His-tagged FabG expressed in Escherichia coli strain BL21 (DE3) | Escherichia coli |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | inhibition by leaf extracts from Acer platanoides, Acer campestre, Acer rubrum, Acer saccharum and Acer truncatum Bunge | Acinetobacter calcoaceticus | |
| additional information | inhibition by leaf extracts from Acer platanoides, Acer campestre, Acer rubrum, Acer saccharum and Acer truncatum Bunge | Enterobacter cloacae | |
| additional information | inhibition by leaf extracts from Acer platanoides, Acer campestre, Acer rubrum, Acer saccharum and Acer truncatum Bunge | Enterococcus sp. | |
| additional information | inhibition by leaf extracts from Acer platanoides, Acer campestre, Acer rubrum, Acer saccharum and Acer truncatum Bunge; inhibition by leaf extracts from Acer platanoides, Acer campestre, Acer rubrum, Acer saccharum and Acer truncatum Bunge. Leaf extracts of Acer saccharum and Acer truncatum Bunge display time-dependent irreversible inhibition of FabG, whereas leaf extracts of Acer platanoides, Acer campestre and Acer rubrum show reversible inhibition | Escherichia coli | |
| additional information | inhibition by leaf extracts from Acer platanoides, Acer campestre, Acer rubrum, Acer saccharum and Acer truncatum Bunge | Klebsiella aerogenes | |
| additional information | inhibition by leaf extracts from Acer platanoides, Acer campestre, Acer rubrum, Acer saccharum and Acer truncatum Bunge | Klebsiella pneumoniae | |
| additional information | inhibition by leaf extracts from Acer platanoides, Acer campestre, Acer rubrum, Acer saccharum and Acer truncatum Bunge. Is inhibited by the leaf extracts from all five kinds of maples more effectively than are other Gram-negative bacteria strains | Proteus vulgaris | |
| additional information | inhibition by leaf extracts from Acer platanoides, Acer campestre, Acer rubrum, Acer saccharum and Acer truncatum Bunge | Pseudomonas aeruginosa | |
| additional information | inhibition by leaf extracts from Acer platanoides, Acer campestre, Acer rubrum, Acer saccharum and Acer truncatum Bunge. Is inhibited by the leaf extracts from all five kinds of maples more effectively than are other Gram-negative bacteria strains | Salmonella enterica subsp. enterica serovar Typhi | |
| additional information | inhibition by leaf extracts from Acer platanoides, Acer campestre, Acer rubrum, Acer saccharum and Acer truncatum Bunge | Salmonella enterica subsp. enterica serovar Typhimurium | |
| additional information | inhibition by leaf extracts from Acer platanoides, Acer campestre, Acer rubrum, Acer saccharum and Acer truncatum Bunge | Serratia marcescens | |
| additional information | inhibition by leaf extracts from Acer platanoides, Acer campestre, Acer rubrum, Acer saccharum and Acer truncatum Bunge. Is inhibited by the leaf extracts from all five kinds of maples more effectively than are other Gram-negative bacteria strains | Shigella dysenteriae | |
| additional information | inhibition by leaf extracts from Acer platanoides, Acer campestre, Acer rubrum, Acer saccharum and Acer truncatum Bunge | Shigella flexneri | |
| additional information | inhibition by leaf extracts from Acer platanoides, Acer campestre, Acer rubrum, Acer saccharum and Acer truncatum Bunge | Shigella sonnei | |
| additional information | inhibition by leaf extracts from Acer platanoides, Acer campestre, Acer rubrum, Acer saccharum and Acer truncatum Bunge | Staphylococcus aureus | |
| additional information | inhibition by leaf extracts from Acer platanoides, Acer campestre, Acer rubrum, Acer saccharum and Acer truncatum Bunge, except strain 04-5 | Staphylococcus epidermidis | |
| quercetin | - |
Escherichia coli |  |
| Tannic acid | - |
Acinetobacter calcoaceticus | |
| Tannic acid | - |
Enterobacter cloacae | |
| Tannic acid | - |
Enterococcus sp. | |
| Tannic acid | strongest inhibition on FabG, shows time-dependent irreversible inhibition | Escherichia coli | |
| Tannic acid | - |
Klebsiella aerogenes | |
| Tannic acid | - |
Klebsiella pneumoniae | |
| Tannic acid | - |
Proteus vulgaris | |
| Tannic acid | - |
Pseudomonas aeruginosa | |
| Tannic acid | - |
Salmonella enterica subsp. enterica serovar Typhi | |
| Tannic acid | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
| Tannic acid | - |
Serratia marcescens | |
| Tannic acid | - |
Shigella dysenteriae | |
| Tannic acid | - |
Shigella flexneri | |
| Tannic acid | - |
Shigella sonnei | |
| Tannic acid | displays very strong inhibition | Staphylococcus aureus | |
| Tannic acid | displays very strong inhibition | Staphylococcus epidermidis | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Acinetobacter calcoaceticus | - |
- |
- |
| Acinetobacter calcoaceticus 25001 | - |
- |
- |
| Enterobacter cloacae | - |
- |
- |
| Enterobacter cloacae 45301 | - |
- |
- |
| Enterococcus sp. | - |
strains ATCC29212 and 775 | - |
| Escherichia coli | - |
- |
- |
| Escherichia coli | - |
strains ATCC 25922 and 26 | - |
| Klebsiella aerogenes | - |
- |
- |
| Klebsiella aerogenes 45102 | - |
- |
- |
| Klebsiella pneumoniae | - |
strains ATCC700603 and 14 | - |
| Proteus vulgaris | - |
- |
- |
| Pseudomonas aeruginosa | - |
strains ATCC27853 and 17 | - |
| Salmonella enterica subsp. enterica serovar Typhi | - |
- |
- |
| Salmonella enterica subsp. enterica serovar Typhi H901 | - |
- |
- |
| Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
| Serratia marcescens | - |
- |
- |
| Serratia marcescens 41002 | - |
- |
- |
| Shigella dysenteriae | - |
- |
- |
| Shigella flexneri | - |
- |
- |
| Shigella sonnei | - |
- |
- |
| Shigella sonnei 51592 | - |
- |
- |
| Staphylococcus aureus | - |
strains ATCC29213, 15 and 05-3 | - |
| Staphylococcus epidermidis | - |
strains ATCC12228, 04-5 and 05-1 | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| by nickel chelation affinity chromatography | Escherichia coli |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -80°C, 50% glycerol | Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ethyl acetoacetate + NADPH | - |
Escherichia coli | ? + NADP+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| beta-ketoacyl-ACP reductase | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
| beta-ketoacyl-ACP reductase | - |
Staphylococcus aureus |
| beta-ketoacyl-ACP reductase | - |
Escherichia coli |
| beta-ketoacyl-ACP reductase | - |
Enterobacter cloacae |
| beta-ketoacyl-ACP reductase | - |
Klebsiella aerogenes |
| beta-ketoacyl-ACP reductase | - |
Pseudomonas aeruginosa |
| beta-ketoacyl-ACP reductase | - |
Acinetobacter calcoaceticus |
| beta-ketoacyl-ACP reductase | - |
Serratia marcescens |
| beta-ketoacyl-ACP reductase | - |
Proteus vulgaris |
| beta-ketoacyl-ACP reductase | - |
Klebsiella pneumoniae |
| beta-ketoacyl-ACP reductase | - |
Staphylococcus epidermidis |
| beta-ketoacyl-ACP reductase | - |
Salmonella enterica subsp. enterica serovar Typhi |
| beta-ketoacyl-ACP reductase | - |
Shigella sonnei |
| beta-ketoacyl-ACP reductase | - |
Shigella dysenteriae |
| beta-ketoacyl-ACP reductase | - |
Shigella flexneri |
| beta-ketoacyl-ACP reductase | - |
Enterococcus sp. |
| FabG | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
| FabG | - |
Staphylococcus aureus |
| FabG | - |
Escherichia coli |
| FabG | - |
Enterobacter cloacae |
| FabG | - |
Klebsiella aerogenes |
| FabG | - |
Pseudomonas aeruginosa |
| FabG | - |
Acinetobacter calcoaceticus |
| FabG | - |
Serratia marcescens |
| FabG | - |
Proteus vulgaris |
| FabG | - |
Klebsiella pneumoniae |
| FabG | - |
Staphylococcus epidermidis |
| FabG | - |
Salmonella enterica subsp. enterica serovar Typhi |
| FabG | - |
Shigella sonnei |
| FabG | - |
Shigella dysenteriae |
| FabG | - |
Shigella flexneri |
| FabG | - |
Enterococcus sp. |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Escherichia coli | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.00078 | - |
- |
Escherichia coli | Tannic acid | |
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