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Literature summary for 1.1.1.100 extracted from

  • Volpe, J.J.; Vagelos, P.R.
    Saturated fatty acid biosynthesis and its regulation (1973), Annu. Rev. Biochem., 42, 21-60.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-oxoacyl-[acyl-carrier protein] + NADPH Escherichia coli first reduction step of fatty acid synthase (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
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?

Organism

Organism UniProt Comment Textmining
Escherichia coli
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-oxoacyl-[acyl-carrier protein] + NADPH
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Escherichia coli (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
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?
3-oxoacyl-[acyl-carrier protein] + NADPH first reduction step of fatty acid synthase Escherichia coli (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
-
?
additional information only D-(-) isomer is oxidized Escherichia coli ?
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?
additional information beta-ketoacyl thioesters of CoA and pantetheine metabolized at slower rates Escherichia coli ?
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?
additional information equally active on beta-ketoacyl-ACP derivatives of C4 to C16 Escherichia coli ?
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?
additional information broad specificity for chain length of substrates Escherichia coli ?
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additional information L-isomer completely inactive Escherichia coli ?
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?

Cofactor

Cofactor Comment Organism Structure
NADPH
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Escherichia coli