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Literature summary for 1.1.1.1 extracted from

  • Plapp, B.V.; Berst, K.B.
    Specificity of human alcohol dehydrogenase 1C*2 (gamma2gamma2) for steroids and simulation of the uncompetitive inhibition of ethanol metabolism (2003), Chem. Biol. Interact., 143-144, 183-193.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of ADH1C*2 in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
3-butylthiolan 1-oxide dead-end inhibitor to the enzyme-cofactor complex, inhibition of oxidation reaction Homo sapiens
4-androsten-3,17-dione competitive against substrate cyclohexanone Homo sapiens
5alpha-androstan-17beta-ol-3-one i.e. 5alpha-dihydrotestosterone, allosteric, competitive against substrate cyclohexanone, noncompetitive against NAD+ nd ethanol Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information steady-state kinetics Homo sapiens
0.003
-
5beta-androstan-3beta-ol-17-one pH 7.3, 37°C, recombinant enzyme Equus caballus
0.0036
-
5alpha-androstan-17beta-ol-3-one pH 7.3, 37°C, ADH1C*2 (gamma2gamma2) Homo sapiens
0.0036
-
5beta-pregnan-3,20-dione pH 7.3, 37°C, ADH1C*2 (gamma2gamma2) Homo sapiens
0.008
-
5beta-cholanic acid-3-one pH 7.3, 37°C, recombinant enzyme Equus caballus
0.011
-
5beta-androstan-17beta-ol-3-one pH 7.3, 37°C, recombinant enzyme Equus caballus
0.027
-
5beta-Pregnan-3beta-ol-20-one pH 7.3, 37°C, ADH1C*2 (gamma2gamma2) Homo sapiens
0.046
-
5beta-androstan-17beta-ol-3-one pH 7.3, 37°C, ADH1C*2 (gamma2gamma2) Homo sapiens
0.058
-
5beta-androstan-3beta-ol-17-one pH 7.3, 37°C, ADH1C*2 (gamma2gamma2) Homo sapiens
0.25
-
5beta-cholanic acid-3-one pH 7.3, 37°C, ADH1C*2 (gamma2gamma2) Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ethanol + NAD+ Homo sapiens
-
acetaldehyde + NADH
-
?

Organism

Organism UniProt Comment Textmining
Equus caballus
-
-
-
Homo sapiens
-
isozyme 1C*2 (gamma2gamma2)
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Equus caballus
-
liver isozyme ADH1C*2 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5alpha-androstan-17beta-ol-3-one + NADH + H+
-
Homo sapiens 3beta,17beta-dihydroxy-5alpha-androstan + NAD+
-
?
5alpha-pregnan-3beta-ol-20-one + NAD+ low activity Homo sapiens 5alpha-pregnan-3,20-dione + NADH
-
?
5beta-androstan-17beta-ol-3-one + NAD+
-
Equus caballus 5beta-androstan-3,17-dione + NADH
-
?
5beta-androstan-17beta-ol-3-one + NAD+ low activity Homo sapiens 5beta-androstan-3,17-dione + NADH
-
?
5beta-androstan-3beta-ol-17-one + NAD+
-
Homo sapiens 5beta-androstan-3,17-dione + NADH
-
?
5beta-androstan-3beta-ol-17-one + NAD+
-
Equus caballus 5beta-androstan-3,17-dione + NADH
-
?
5beta-cholanic acid-3-one + NADH low activity Homo sapiens 5beta-cholanic acid-3-ol + NAD+
-
?
5beta-cholanic acid-3-one + NADH + H+
-
Equus caballus 5beta-cholanic acid-3-ol + NAD+
-
?
5beta-pregnan-3,20-dione + NADH
-
Homo sapiens ?
-
?
5beta-pregnan-3beta-ol-20-one + NAD+
-
Homo sapiens 5beta-pregnan-3,20-dione + NADH
-
?
cyclohexanone + NADH + H+
-
Homo sapiens cyclohexanol + NAD+
-
?
ethanol + NAD+
-
Homo sapiens acetaldehyde + NADH
-
?
ethanol + NAD+
-
Equus caballus acetaldehyde + NADH
-
?

Synonyms

Synonyms Comment Organism
ADH1C*1
-
Homo sapiens
ADH1C*2
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30 37 assay at Homo sapiens
30 37 assay at Equus caballus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.3
-
assay at Homo sapiens
7.3
-
assay at Equus caballus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens
NAD+
-
Equus caballus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information inhibition kinetics Homo sapiens
0.0047
-
5alpha-androstan-17beta-ol-3-one pH 7.3, 37°C, versus cyclohexanone Homo sapiens
0.0047
-
4-androsten-3,17-dione pH 7.3, 37°C, versus cyclohexanone Homo sapiens
0.014
-
5alpha-androstan-17beta-ol-3-one pH 7.3, 37°C, versus ethanol Homo sapiens
0.028
-
5alpha-androstan-17beta-ol-3-one pH 7.3, 37°C, versus NAD+ Homo sapiens