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Literature summary for 1.1.1.1 extracted from
- Determination of some biochemical and structural features of alcohol dehydrogenases from Drosophila simulans and Drosophila virilis. Comparison of their properties with the Drosophila melanogaster Adhs enzyme (1981), Biochem. J., 195, 61-69.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.19 | - |
NAD+ | - |
Drosophila simulans |  |
| 0.2 | - |
NAD+ | - |
Drosophila virilis | |
| 0.26 | - |
NAD+ | - |
Drosophila melanogaster | |
| 0.41 | - |
butan-2-ol | - |
Drosophila simulans | |
| 0.86 | - |
butan-2-ol | - |
Drosophila melanogaster | |
| 0.93 | - |
propan-2-ol | - |
Drosophila simulans | |
| 1.6 | - |
butan-2-ol | - |
Drosophila virilis | |
| 1.87 | - |
propan-2-ol | - |
Drosophila melanogaster | |
| 1.99 | - |
propan-2-ol | - |
Drosophila virilis | |
| 3.01 | - |
butan-1-ol | - |
Drosophila simulans | |
| 3.31 | - |
butan-1-ol | - |
Drosophila melanogaster | |
| 3.33 | - |
propan-2-ol | - |
Drosophila simulans | |
| 3.42 | - |
propan-2-ol | - |
Drosophila melanogaster | |
| 4.16 | - |
propan-2-ol | - |
Drosophila virilis | |
| 5.22 | - |
ethanol | - |
Drosophila simulans | |
| 6.44 | - |
ethanol | - |
Drosophila virilis | |
| 8.92 | - |
ethanol | - |
Drosophila melanogaster | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 27800 | - |
2 * 27800, SDS-PAGE | Drosophila melanogaster |
| 27800 | - |
2 * 27800, SDS-PAGE | Drosophila virilis |
| 27800 | - |
2 * 27800, SDS-PAGE | Drosophila simulans |
| 54600 | - |
gel filtration | Drosophila virilis |
| 55600 | - |
gel filtration | Drosophila melanogaster |
| 57600 | - |
gel filtration | Drosophila simulans |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Drosophila melanogaster | - |
- |
- |
| Drosophila simulans | - |
- |
- |
| Drosophila virilis | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| butan-2-ol + NAD+ | - |
Drosophila melanogaster | butan-2-one + NADH | - |
? | |
| butan-2-ol + NAD+ | - |
Drosophila virilis | butan-2-one + NADH | - |
? | |
| butan-2-ol + NAD+ | - |
Drosophila simulans | butan-2-one + NADH | - |
? | |
| butanol + NAD+ | - |
Drosophila melanogaster | butyraldehyde + NADH | - |
? | |
| butanol + NAD+ | - |
Drosophila virilis | butyraldehyde + NADH | - |
? | |
| butanol + NAD+ | - |
Drosophila simulans | butyraldehyde + NADH | - |
? | |
| ethanol + NAD+ | - |
Drosophila melanogaster | acetaldehyde + NADH | - |
? | |
| ethanol + NAD+ | - |
Drosophila virilis | acetaldehyde + NADH | - |
? | |
| ethanol + NAD+ | - |
Drosophila simulans | acetaldehyde + NADH | - |
? | |
| propan-2-ol + NAD+ | - |
Drosophila melanogaster | acetone + NADH | - |
? | |
| propan-2-ol + NAD+ | - |
Drosophila virilis | acetone + NADH | - |
? | |
| propan-2-ol + NAD+ | - |
Drosophila simulans | acetone + NADH | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 27800, SDS-PAGE | Drosophila melanogaster |
| dimer | 2 * 27800, SDS-PAGE | Drosophila virilis |
| dimer | 2 * 27800, SDS-PAGE | Drosophila simulans |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
and second optimum at pH 9.9 | Drosophila simulans |
| 8 | - |
and a second optimum at pH 9.5 | Drosophila melanogaster |
| 8 | - |
and a second optimum at pH 9.5 | Drosophila virilis |
| 9.5 | - |
and a second optimum at pH 8.0 | Drosophila melanogaster |
| 9.5 | - |
and a second optimum at pH 8.0 | Drosophila virilis |
| 9.9 | - |
and second optimum at pH 7.5 | Drosophila simulans |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Drosophila melanogaster | |
| NAD+ | - |
Drosophila virilis | |
| NAD+ | - |
Drosophila simulans | |
| NADH | - |
Drosophila melanogaster | |
| NADH | - |
Drosophila virilis | |
| NADH | - |
Drosophila simulans | |
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