Ligand diethyldithiocarbamate

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Basic Ligand Information

Molecular Structure
Picture of diethyldithiocarbamate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H11NS2
diethyldithiocarbamate
LMBWSYZSUOEYSN-UHFFFAOYSA-N
Synonyms:
Diethyl dithiocarbamate, diethyldithiocarbamic acid, diethyldithiocarbaminate, Diethylthiocarbamoyl sulfide, Et2NCS2-, N,N-diethyldithiocarbamate

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
diethylthiocarbamoyl sulfide + S-adenosyl-L-methionine = ? + S-adenosyl-L-homocysteine
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
without protein-A: 30% activation at 0.1 mM
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inhibits superoxide dismutase
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35% increase of activity at 1 mM
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activation
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stimulation of nitrite production at 0.1 mM
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activation
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Inhibitor in Enzyme-catalyzed Reactions (172 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive
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10 mM, 28% inhibition
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95% inactivation, prevented by presence of 2-mercaptoethanol
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in 100 mM MES buffer (pH 6.5) with 200 mM NADPH, 0.25 mM decanal, and 125 microg of FALDR fusion protein. 1 mM inhibits by 50%, 0.25 mM inhibits by 39%
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50% inhibition at 2 mM
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50% inhibition at a concentration of 50 mM
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slight inhibition, 2 mM, 10 mM
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40.1% inhibition at 1 mM
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87% inhibition at 1 mM
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significant inhibition of selenium-dependent enzyme after intraperitoneal injection of rats with diethyldithiocarbamate, which returns to normal at 48 h after administration of injection. It is possible that inhibition of superoxide dismutase by diethyldithiocarbamate leads to accumulation of superoxide anion which in turn inactivates selenium-dependent glutathione peroxidase by its reaction with slenium at the active site of the enzyme
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70% inhibition at 10 mM
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reversible by addition of Cu2+
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5 mM 30 min
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0.1 mM, 37% inhibition
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10% inhibition at 0.02 mM
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inhibits after a prolonged incubation time
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50% inhibition at 0.002-0.003 mM
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CYP2E1
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reduces activity to 88%
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0.5 mM, 16% inhibition
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0.3 mM, complete inhibition
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2 mM, 7% loss of activity
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2 mM, 80% inhibition
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1 mM, complete inhibition
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72% inhibition of xanthine-NAD+-activity at 10 mM
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50% inhibition at 0.4 mM
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10 mM, completely suppressed in vitro
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inhibition of nitrate production at 0.1 mM
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slightly inhibits
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2 mM, 36% inhibition
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1 mM, 94% inhibition
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23% inhibition at 0.2 mM
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weak, with p-nitrophenyl-beta-D-glucopyranoside as substrate
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0.1 mM
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1 mM, 40.6% inhibition
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3D Structure of Enzyme-Ligand-Complex (PDB) (2 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

KM Value (2 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

Ki Value (21 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
TABLE ID

IC50 Value (2 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE

References & Links

Links to other databases for diethyldithiocarbamate

ChEBI
PubChem
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PubChem