Ligand NaCN

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Basic Ligand Information

Molecular Structure
Picture of NaCN (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
CNNa
NaCN
MNWBNISUBARLIT-UHFFFAOYSA-N

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
O-acetyl-L-Ser + NaCN = beta-cyanoalanine + sodium acetate
show the reaction diagram
-
L-cysteine + NaCN = L-3-cyanoalanin + Na2S
show the reaction diagram
-

Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
1 mM, relative activity 104%
-
10 mM , enhances activity
-

Inhibitor in Enzyme-catalyzed Reactions (68 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
slight inhibition at 1 mM
-
1 mM, 50% inhibition
-
41% inhibition at 2 mM
-
1 mM inhibits
-
1 mM, 51.9% inhibition
-
Co QueD: 91% activity remains after 15 min incubation with 1 mM reagent, Mn QueD: 89% activity remains after 15 min incubation with 1 mM reagent
-
69% inhibition of xanthine-NAD+-activity at 3.3 mM
-
91.4% residual activity at 1 mM
-
slight
-
1 mM, 12% inhibition
-
5 mM, 40% inhibition
-
50% inhibition at 3-5 mM
-
slightly inhibitory
-
0.1%
-
60.6% residual activity at 0.1 M using inosine as substrate, 38.7% residual activity at 0.1 M using guanosine as substrate, 41.6% residual activity at 0.1 M using adenosine as substrate
-
very slight inhibition
-
31% inhibition at 5 mM
-
non-competitive inhibition
-
1 mM, 42% inhibition
-
0.6 mM, 20% inhibition
-
2.5 mM, 21% inhibition
-
1 mM completely inhibits mercury volatilization activities with reduced cytochrome c and 2,3,5,6-tetramethyl-p-phenylendiamine in strain MON-1
-

Enzyme Kinetic Parameters

KM Value (3 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
5.2
-
pH 7.4, 30°C

Ki Value (4 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
TABLE ID
0.13
-
pH 7.5, 25°C, non-competitive with acrylonitrile
39626

References & Links

Links to other databases for NaCN

ChEBI
PubChem
ChEBI
PubChem