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  • Metals and Ions
  • 3D Structure (PDB)
• Enzyme Kinetic Parameters
• • k_cat Value (Turnover Number)
  • K_M Value
  • K_i Value
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• • References
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Ligand gentamicin C1

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (5 results)

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Show Substrate (5 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.59

acetyl-CoA + gentamicin C1 = CoA + N2'-acetylgentamicin C1

487272, 487273

-

2.3.1.60

acetyl-CoA + gentamicin C1 = CoA + N3'-acetylgentamicin C1

637302

-

2.3.1.81

acetyl-CoA + gentamicin C1 = CoA + N3'-acetylgentamicin C1

637299, 637300

-

2.3.1.82

acetyl-CoA + gentamicin C1 = CoA + N6'-acetylgentamicin C1

636903

-

2.7.7.46

ATP + gentamicin C1 = diphosphate + 2''-adenylylgentamicin C1

637300, 645289

-

Activator in Enzyme-catalyzed Reactions (1 result)

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Show Activating Compound (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

3.6.5.3

-

644144

-

Inhibitor in Enzyme-catalyzed Reactions (3 results)

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Show Inhibitors (3 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.82

-

636899

-

2.3.1.82

competitive inhibitor of neamine, non-competitive inhibitor of acetyl-CoA

636902

-

2.3.1.82

2 entries

2.7.7.46

-

645290

-

Enzyme Kinetic Parameters

K_M Value (1 result)

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Show KM Value (1 entry)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.3.1.81

0.066

-

-

637300

K_i Value (2 results)

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Show KI Value (2 entries)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

TABLE ID

2.3.1.82

4

-

pH 6.9, 37°C, inhibition of the reaction with neamine

636902

10240

2.7.7.46

1.84

-

-

645290

16224

References & Links

Literature References (11)

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Show Reference (11 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

487272

4209515

Aminoglycoside antibiotic-inactivating enzymes in actinomycetes similar to those present in clinical isolates of antibiotic-resistant bacteria

1973

Benveniste, R.; Davies, J.

Proc. Natl. Acad. Sci. USA

70

2276-2280

487273

4810068

Aminoglycoside resistance in bacteria medicated by gentamicin acetyltransferase II, an enzyme modifying the 2-amino group of aminoglycoside antibiotics

1974

Chevereau, M.; Daniels, P.J.L.; Davies, J.; LeGoffic, F.

Biochemistry

13

598-603

636899

4614862

Resistance to aminosides induced by an isoenzyme, kanamycin acetyltransferase

1974

Le Goffic, F.; Martel, A.

Biochimie

56

893-897

636902

6305650

Kinetic studies of aminoglycoside acetyltransferase and phosphotransferase from Staphylococcus aureus RPAL. Relationship between the two activities

1983

Martel, A.; Masson, M.; Moreau, N.; Le Goffic, F.

Eur. J. Biochem.

133

515-521

636903

1577689

Genetic analysis of bacterial acetyltransferases: identification of amino acids determining the specificities of the aminoglycoside 6-N-acetyltransferase Ib and IIa proteins

1992

Rather, P.N.; Munayyer, H.; Mann, P.A.; Hare, R.S.; Miller, G.H.; Shaw, K.J.

J. Bacteriol.

174

3196-3203

637299

820250

Enzymatic modification of aminoglycoside antibiotics: a new 3-N-acetylating enzyme from a Pseudomonas aeruginosa isolate

1976

Biddlecome, S.; Haas, M.; Davies, J.; Rane, D.F.; Daniels, P.J.L.

Antimicrob. Agents Chemother.

9

951-955

637300

6281224

Purification and properties of two gentamicin-modifying enzymes, coded by a single plasmid pPK237 originating from Pseudomonas aeruginosa

1982

Angelatou, F.; Litsas, S.B.; Kontomichalou, P.

J. Antibiot.

35

235-244

637302

681328

Substrate specificity and structure-activity relationships of gentamicin acetyltransferase I. The dependence of antibiotic resistance upon substrate Vmax/Km values

1978

Williams, J.W.; Northrop, D.B.

J. Biol. Chem.

253

5908-5914

644144

6114863

Effects of antibiotics, N-acetylaminoacyl-tRNA and other agents on the elongation-factor Tu dependent and ribosome-dependent GTP hydrolysis promoted by 2'(3')-O-L-phenylalanyladenosine

1981

Campuzano, S.; Modolell, J.

Eur. J. Biochem.

117

27-31

645289

2841976

Alternative substrate and inhibition kinetics of aminoglycoside nucleotidyltransferase 2''-I in support of a Theorell-Chance kinetic mechanism

1988

Gates, C.A.; Northrop, D.B.

Biochemistry

27

3826-3833

645290

2841977

Determination of the rate-limiting segment of aminoglycoside nucleotidyltransferase 2''-I by pH- and viscosity-dependent kinetics

1988

Gates, C.A.; Northrop, D.B.

Biochemistry

27

3834-3842

Links to other databases for gentamicin C1

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Show Links (1 entry)

ChEBI

PubChem

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