Ligand phosphatidylethanolamine

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Basic Ligand Information

Molecular Structure
Picture of phosphatidylethanolamine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C13H24NO8PR2
phosphatidylethanolamine
OLWIBMXICSDFED-NSHDSACASA-N
Synonyms:
(3-phosphatidyl)-ethanolamine, (3-phosphatidyl)ethanolamine, 1,2-diacylglycero-3-phosphorylethanolamine, a phosphatidylethanolamine, diacyl-sn-glycero-3-phosphorylethanolamine, L-1-phosphatidylethanolamine, L-alpha-Phosphatidylethanolamine, O-(1,2-diacyl-sn-glycero-3-phospho) ethanolamine, O-(1,2-diacyl-sn-glycero-3-phospho)ethanolamine, O-(1-beta-acyl-2-acyl-sn-glycero-3-phospho) ethanolamine, O-(1-beta-acyl-2-acyl-sn-glycero-3-phospho)ethanolamine, phosphatidyl ethanolamine


Show all pahtways known for Show all BRENDA pathways known for phosphatidylethanolamine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-1-phosphatidylethanolamine + L-serine = L-1-phosphatidylserine + ethanolamine
show the reaction diagram
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a phosphatidylglycerol + a phosphatidylethanolamine = a cardiolipin + ethanolamine
show the reaction diagram
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a ceramide + a phosphatidylethanolamine = a ceramide phosphoethanolamine + a 1,2-diacyl-sn-glycerol
show the reaction diagram
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phosphatidylethanolamine + H2O = diacylglycerol + ethanolamine phosphate
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
CDP-ethanolamine + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylethanolamine
show the reaction diagram
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Phosphatidyl-L-serine = Phosphatidylethanolamine + CO2
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Substrate in Enzyme-catalyzed Reactions (43 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
phosphatidylethanolamine + NADH + H+ + O2 = ?
show the reaction diagram
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S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
show the reaction diagram
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S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + ?
show the reaction diagram
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S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-monomethylethanolamine
show the reaction diagram
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S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + ?
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phosphatidylethanolamine + 1,2-diacylglycerol = 2-lysophosphatidylethanolamine + triacylglycerol
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phosphatidylethanolamine + [apolipoprotein FSL-1]-S-1,2-diacyl-sn-glyceryl-L-cysteine = 1-lyso-phosphatidylethanolamine + [lipoprotein FSL-1]-N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteine
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phosphatidylethanolamine + cholesterol = cholesteryl ester + lysophosphatidylethanolamine
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acetyl-CoA + phosphatidylethanolamine = CoA + N-acetylphosphatidylethanolamine
show the reaction diagram
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L-1-phosphatidylethanolamine + L-serine = L-1-phosphatidylserine + ethanolamine
show the reaction diagram
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a phosphatidylglycerol + a phosphatidylethanolamine = a cardiolipin + ethanolamine
show the reaction diagram
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a ceramide + a phosphatidylethanolamine = a ceramide phosphoethanolamine + a 1,2-diacyl-sn-glycerol
show the reaction diagram
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phosphatidylethanolamine + H2O = ?
show the reaction diagram
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phosphatidylethanolamine + H2O = ?
show the reaction diagram
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phosphatidylethanolamine + H2O = ?
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (15 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acyl-(acyl-carrier protein) + O-(2-acyl-sn-glycero-3-phospho) ethanolamine = (acyl-carrier protein) + O-(1,2-diacyl-sn-glycero-3-phospho) ethanolamine
show the reaction diagram
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phosphatidylcholine + ethanolamine = phosphatidylethanolamine + choline
show the reaction diagram
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Phosphatidyl-L-serine = Phosphatidylethanolamine + CO2
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (75 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
144% activity at 0.1 mg per g wet weight of cells
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3.9fold activation at 0.5 mg/ml
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activates at low concentration
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more than 3fold activation
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incorporation in membrane elevates acyltransferase activity
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weak stimulatory effect on activity
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stimulates
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increases 125% of activity
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activation, less efficient than Triton CF-54
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activation
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mild activity-enhancing effect (60%, at 40 mol percent concentration)
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activates
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requirement, most effective phospholipid, phosphatidylethanolamine containing unsaturated or cyclopropane acyl groups is more effective than that containing saturated acyl groups
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activation
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activation
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stimulated by after dialysis
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activation
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stimulates 5fold 0.36 mM
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stimulates activity of enzyme in endoplasmic membrane vesicles
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activates
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stimulates, no stimulation by other diacylglycerophosphatides or lysophosphatides
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slightly activates. The enzyme is completely desensitized by treatment for 5 min at 40°C against the effect of phosphatidylethanolamine without loss of activity
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activates
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slightly activating
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0.075 mM, approx. 6fold activation upon incorporation into cholestryl oleate liquid crystals
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1fold stimulation of hydrophilic enzyme form
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stimulation
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phospholipase C is enhanced by cholesterol and by lipids with an intrinsic negative curvature, e.g. phosphatidylethanolamine
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activation
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activates; activates 5.91fold at 1 mM
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stimulation
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activation, in the presence of 3.5 mM Triton X-100
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8fold stimulation at 0.002%
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is required to maintain activity of the membrane-incorporated signal-peptidase (full-length signal peptidase I incoporated into phospholipid vesicles). Maximal activity is achieved at about 55% phosphatidylethanolamine
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enhances autofragmentation and serine protease activity at 0.001 mg/ml and 0.00001 mg/ml
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requirement, phosphatidylcholine is preferred, phopshatidylserine and phopshatidylethanolamine substitute less effectively
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slight stimulation, acyl-CoA synthetase II
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non-bilayer lipid essential for high activity of OpuA
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Inhibitor in Enzyme-catalyzed Reactions (26 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
1,2-unsaturated species
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above 1.5 mM
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inhibition alone, synergistic activation with the protein peak eluted from hydroxylapatite by 25 mM phosphate
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2 mM, 16% inhibition
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3 mM, 70% inhibition. competitive
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25% inhibition, in presence of 0.001 mM Ca2+
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3D Structure of Enzyme-Ligand-Complex (PDB) (23 results)

Enzyme Kinetic Parameters

KM Value (13 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.53
-
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0.92
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Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
2.7
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pH 7.5, 23°C

References & Links

Links to other databases for phosphatidylethanolamine

ChEBI
PubChem
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PubChem