Ligand [acyl-carrier protein]

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Basic Ligand Information

Molecular Structure
Picture of [acyl-carrier protein] (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C14H26N3O8PR2S
[acyl-carrier protein]
WYMWMUXNYKPHMQ-UHFFFAOYSA-N
Synonyms:
(acyl-carrier protein), ACP, acyl-carrier-protein, acyl-carrier protein, Acyl carrier protein, a holo-[acyl-carrier protein], an [acyl-carrier protein], apo-ACP, a [acyl-carrier protein], BtrI acyl-carrier protein, Clostridium butyricum acyl-carrier protein, E. coli acyl-carrier protein, holo-acyl-carrier protein, holo-[acyl-carrier protein AcpA], holo-[acyl-carrier protein], holo-[fredericamycin acyl-carrier protein], holo-[Streptomyces sp. frenolicin-acyl-carrier protein], holo-[Streptomyces sp. granaticin-acyl-carrier protein], holo-[Streptomyces sp. oxytetracycline-acyl-carrier protein], holo-[Streptomyces sp. tetracenomycin-acyl-carrier protein(His6)], holo-[tetracenomycin M acyl-carrier protein], Rat liver cytosol carrier protein, spinach acyl-carrier protein, Sterol carrier protein, [Acyl-carrier-protein], [acyl-carrier protein 1], [acyl-carrier protein 2], [acyl-carrier protein 3], [acyl carrier protein], [citrate (pro-3S)-lyase](thiol form)


Show all pahtways known for Show all BRENDA pathways known for [acyl-carrier protein]

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acetyl-CoA + [acyl-carrier protein] = CoA + acetyl-[acyl-carrier protein]
show the reaction diagram
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acyl-carrier protein + H2O = 4'-phosphopantetheine + apoprotein
show the reaction diagram
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ATP + L-glutamate + BtrI acyl-carrier protein = ADP + phosphate + L-glutamyl-[BtrI acyl-carrier protein]
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (73 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acyl-[acyl-carrier protein] + sn-glycerol 3-phosphate = acyl-carrier protein + 1-acyl-sn-glycerol 3-phosphate
show the reaction diagram
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(Z)-hexadec-11-enoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = (Z)-3-oxooctadec-13-enoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
show the reaction diagram
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7 malonyl-CoA + hexanoyl-[acyl-carrier protein] = 7 CoA + norsolorinic acid anthrone + [acyl-carrier protein] + 7 CO2 + 2 H2O
show the reaction diagram
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a dodecanoyl-[acyl-carrier protein] + (3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-2-[[(3R)-3-hydroxytetradecanoyl]amino]-3-O-[(3R)-3-hydroxytetradecanoyl]-4-O-phosphono-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose = (3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-2-[[(3R)-3-(dodecanoyloxy)tetradecanoyl]amino]-3-O-[(3R)-3-hydroxytetradecanoyl]-4-O-phosphono-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose + an [acyl-carrier protein]
show the reaction diagram
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a tetradecanoyl-[acyl-carrier protein] + (3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-2-[[(3R)-3-dodecanoyloxytetradecanoyl]amino]-3-O-[(3R)-3-hydroxytetradecanoyl]-4-O-phosphono-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose = (3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-2-[[(3R)-3-(dodecanoyloxy)tetradecanoyl]amino]-3-O-[(3R)-3-(tetradecanoyloxy)tetradecanoyl]-4-O-phosphono-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose + an [acyl-carrier protein]
show the reaction diagram
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a lyso-ornithine lipid + an acyl-[acyl-carrier protein] = an ornithine lipid + a holo-[acyl-carrier protein]
show the reaction diagram
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a medium-chain 3-oxoacyl-[acyl-carrier protein] + glycerone phosphate = 2-oxo-3-(phosphooxy)propyl 3-oxoalkanoate + a holo-[acyl-carrier protein]
show the reaction diagram
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pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein]
show the reaction diagram
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acyl-[acyl-carrier protein] + 1-acyl-sn-glycerol 3-phosphate = ACP + 1,2-diacyl-sn-glycerol 3-phosphate
show the reaction diagram
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L-ornithine + a (3R)-3-hydroxyacyl-[acyl-carrier protein] = a lyso-ornithine lipid + a holo-[acyl-carrier protein]
show the reaction diagram
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[citrate (pro-3S)-lyase](acetyl form) + H2O = [citrate (pro-3S)-lyase](thiol form) + acetate
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (58 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acyl-CoA + [acyl-carrier protein] = acyl-[acyl-carrier protein] + CoA
show the reaction diagram
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apo-ACP + ATP = AMP-ACP + diphosphate
show the reaction diagram
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acetyl-CoA + acyl-carrier protein = CoA + acetyl-[acyl-carrier protein]
show the reaction diagram
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acyl carrier protein + H2O = ?
show the reaction diagram
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acyl-carrier protein + acetate + ATP = acetyl-acyl carrier protein + AMP + diphosphate
show the reaction diagram
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ATP + D-Ala + acyl-carrier protein = D-Alanyl-acyl-carrier protein + AMP + diphosphate
show the reaction diagram
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acyl-carrier protein + H2O + Ca2+/in = ?
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (238 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
stearoyl-[acyl-carrier protein] + 2-acyl-3-D-galactosyl-sn-glycerol = acyl-carrier protein + 2-acyl-3-D-galactosyl-1-stearoyl-sn-glycerol
show the reaction diagram
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7 malonyl-CoA + hexanoyl-[acyl-carrier protein] = 7 CoA + norsolorinic acid anthrone + [acyl-carrier protein] + 7 CO2 + 2 H2O
show the reaction diagram
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isovaleryl-ACP + S-adenosyl-L-methionine = ACP + S-methyl-5'-thioadenosine + N-isovaleryl-L-homoserine lactone
show the reaction diagram
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malonyl-[acyl-carrier protein] + 2-aminobenzoyl-CoA = CoA + acyl-carrier protein + 4-hydroxy-2(1H)-quinolone + CO2
show the reaction diagram
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a lyso-ornithine lipid + an acyl-[acyl-carrier protein] = an ornithine lipid + a holo-[acyl-carrier protein]
show the reaction diagram
-
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a medium-chain 3-oxoacyl-[acyl-carrier protein] + glycerone phosphate = 2-oxo-3-(phosphooxy)propyl 3-oxoalkanoate + a holo-[acyl-carrier protein]
show the reaction diagram
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acyl-(acyl-carrier protein) + O-(2-acyl-sn-glycero-3-phospho) ethanolamine = (acyl-carrier protein) + O-(1,2-diacyl-sn-glycero-3-phospho) ethanolamine
show the reaction diagram
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pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein]
show the reaction diagram
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L-ornithine + a (3R)-3-hydroxyacyl-[acyl-carrier protein] = a lyso-ornithine lipid + a holo-[acyl-carrier protein]
show the reaction diagram
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[citrate (pro-3S)-lyase](acetyl form) + H2O = [citrate (pro-3S)-lyase](thiol form) + acetate
show the reaction diagram
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octanoyl-ACP + lipoyl protein = octanoylated lipoyl protein + ACP
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
from cytosol, required for activity, probably identical with lipid transfer protein
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PAK II: inhibition, PAK I: stimulation between 0.015-0.035 mM
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enhances lanosterol synthase activity in placental microsomes
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Inhibitor in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
0.00056 mg/0.6 ml, 68% reduction of activity
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0.0017 mM, 50% inhibition of myristic acid transfer from myristoyl-[acyl-carrier protein] to wild-type enzyme
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competitive inhibitor with respect to (3R)-3-hydroxymyristoyl-[acyl-carrier protein] and a noncompetitive inhibitor with respect to UDP-3-O-((3R)-3-hydroxymyristoyl)-alpha-D-glucosamine
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at high concentration
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wild-type synthase I and mutants, not mutants C163S and K328A, overview
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acylated derivatives, acyls with chain lengths from C6:0 to C20:1 are inhibitory, 0.04 mM results in 60-70% inhibition, complete inhibition not achieved even with very high concentrations
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Enzyme Kinetic Parameters

KM Value (30 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.035
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0.0017
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Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for [acyl-carrier protein]

ChEBI
PubChem
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PubChem