Ligand trimethylamine

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Basic Ligand Information

Molecular Structure
Picture of trimethylamine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C3H9N
trimethylamine
GETQZCLCWQTVFV-UHFFFAOYSA-N
Synonyms:
(CH3)3N, N,N,N-trimethylamine, N-trimethylammonium, Trimethylammonium


Show all pahtways known for Show all BRENDA pathways known for trimethylamine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N,N,N-trimethylamine + NADPH + H+ + O2 = N,N,N-trimethylamine N-oxide + NADP+ + H2O
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N,N,N-trimethylglycine + phosphate + thioredoxin = acetyl phosphate + trimethylamine + thioredoxin disulfide
show the reaction diagram
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-
choline = trimethylamine + acetaldehyde
show the reaction diagram
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-

Substrate in Enzyme-catalyzed Reactions (23 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
trimethylamine + NADH + H+ + O2 = ?
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (18 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N,N,N-trimethylglycine + phosphate + thioredoxin = acetyl phosphate + trimethylamine + thioredoxin disulfide
show the reaction diagram
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trimethylamine N-oxide + reduced benzyl viologen = trimethylamine + oxidized benzyl viologen + H2O
show the reaction diagram
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tetramethylammonium + a [Co(I) tetramethylammonium-specific corrinoid protein] = a [methyl-Co(III) tetramethylammonium-specific corrinoid protein] + trimethylamine
show the reaction diagram
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choline = trimethylamine + acetaldehyde
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (17 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
L-carnitine dehydrogenase, strong inhibition
-
competitive dead-end inhibitor with respect to choline, uncompetitive with respect to PAPS
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uncompetitive inhibitor
-
reaction of component I with NH4+ as substrate
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3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (21 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (34 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.00118
-
with NADH as cosubstrate, at pH 7.0 and 25°C

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
2.4
-
pH 8.0, 25°C
0.75
-
-

References & Links

Links to other databases for trimethylamine

ChEBI
PubChem
ChEBI
PubChem