Ligand D-mannose 6-phosphate

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Basic Ligand Information

Molecular Structure
Picture of D-mannose 6-phosphate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H13O9P
D-mannose 6-phosphate
NBSCHQHZLSJFNQ-QTVWNMPRSA-N
Synonyms:
6-O-phosphono-D-mannopyranose, 6-phospho-D-mannose, D-mannose-6-phosphate, mannose-6-phosphate, mannose 6-phosphate


Show all pahtways known for Show all BRENDA pathways known for D-mannose 6-phosphate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
phosphoenolpyruvate + D-mannose 6-phosphate + H2O = 3-deoxy-D-glycero-D-galacto-nononate 9-phosphate + phosphate
show the reaction diagram
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D-glucose + D-mannose 6-phosphate = D-glucose 6-phosphate + D-mannose
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-mannitol 1-phosphate + NADP+ = D-mannose 6-phosphate + NADPH + H+
show the reaction diagram
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ATP + D-mannose = ADP + D-mannose 6-phosphate
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(phosphate)n + mannose = (phosphate)n-1 + mannose 6-phosphate
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ATP + D-mannose = ADP + D-mannose 6-phosphate
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D-fructose 6-phosphate = D-mannose 6-phosphate
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alpha-D-mannose 1-phosphate = D-mannose 6-phosphate
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alpha-D-mannose 1-phosphate = D-mannose 6-phosphate
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (26 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-mannose 6-phosphate + NADPH = ?
show the reaction diagram
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phosphoenolpyruvate + D-mannose 6-phosphate + H2O = 3-deoxy-D-glycero-D-galacto-nononate 9-phosphate + phosphate
show the reaction diagram
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D-glucose + D-mannose 6-phosphate = D-glucose 6-phosphate + D-mannose
show the reaction diagram
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D-mannose 6-phosphate + H2O = D-mannose + phosphate
show the reaction diagram
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D-mannose 6-phosphate + H2O = D-mannose + phosphate
show the reaction diagram
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D-mannose 6-phosphate + H2O = D-mannose + phosphate
show the reaction diagram
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D-mannose 6-phosphate + H2O = D-mannose + phosphate
show the reaction diagram
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D-mannose 6-phosphate + H2O = ?
show the reaction diagram
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D-mannose 6-phosphate + H2O = D-mannose + phosphate
show the reaction diagram
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D-mannose 6-phosphate + H2O = D-mannose + phosphate
show the reaction diagram
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D-Mannose 6-phosphate = D-Fructose 6-phosphate
show the reaction diagram
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D-Mannose 6-phosphate = myo-Inositol 1-phosphate
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Product in Enzyme-catalyzed Reactions (38 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-mannitol 1-phosphate + NADP+ = D-mannose 6-phosphate + NADPH + H+
show the reaction diagram
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ADP + D-mannose = AMP + D-mannose 6-phosphate
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ATP + D-mannose = ADP + D-mannose 6-phosphate
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ATP + D-mannose = ADP + D-mannose 6-phosphate
show the reaction diagram
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ATP + D-mannose = ADP + D-mannose 6-phosphate
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D-mannose + acetyl phosphate = D-mannose 6-phosphate + acetate
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2-O-(6-phospho-alpha-D-mannosyl)-D-glycerate + H2O = D-mannose 6-phosphate + D-glycerate
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D-fructose 6-phosphate = D-mannose 6-phosphate
show the reaction diagram
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D-fructose 6-phosphate = D-mannose 6-phosphate
show the reaction diagram
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D-Mannose 1-phosphate = D-Mannose 6-phosphate
show the reaction diagram
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D-Mannose + alpha-D-glucose 1-phosphate = D-Mannose 6-phosphate + D-glucose
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Activator in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activates isoenzyme Hex II
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activates
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Inhibitor in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
potent inhibitor, IC50: 0.0075 mM
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Niemann-Pick disease fibroblasts
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (37 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (74 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
9
-
Vmax: 2.6 micromol/min/mg

Ki Value (3 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
2.3
-
50°C, pH 7.5, D-fructose 6-phosphate as substrate

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.0075
-
potent inhibitor, IC50: 0.0075 mM

References & Links

Links to other databases for D-mannose 6-phosphate

ChEBI
PubChem
ChEBI
PubChem