Ligand prostaglandin H2

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Basic Ligand Information

Molecular Structure
Picture of prostaglandin H2 (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C20H32O5
prostaglandin H2
YIBNHAJFJUQSRA-YNNPMVKQSA-N
Synonyms:
(5Z)-7-{(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl}hept-5-enoic acid, (5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate, (5Z,13E)-(15S)-9a,11a-epidioxy-15-hydroxyprosta-5,13-dienoate, (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate, (5Z,13E)-(15S)-9alpha, 11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate, (5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate, prostaglandin PGH2


Show all pahtways known for Show all BRENDA pathways known for prostaglandin H2

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (28 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
NADPH + H+ + prostaglandin H2 = NADP+ + prostaglandin F2alpha
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (39 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
prostaglandin H2 + [reduced NADPH-hemoprotein reductase] + O2 = 19-hydroxy-prostaglandin H2 + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
-
NADPH + H+ + prostaglandin H2 = NADP+ + prostaglandin F2alpha
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
suicide inactivation
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (27 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
2.45
-
-

KM Value (90 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

IC50 Value (2 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE

References & Links

Links to other databases for prostaglandin H2

ChEBI
PubChem
ChEBI
PubChem