Ligand sarcosine

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Basic Ligand Information

Molecular Structure
Picture of sarcosine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C3H7NO2
sarcosine
FSYKKLYZXJSNPZ-UHFFFAOYSA-N
Synonyms:
2-(methylamino)acetic acid, CH3-NH-CH2-COOH, N-methyl-glycine, N-methylglycine


Show all pahtways known for Show all BRENDA pathways known for sarcosine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N-methylglycine + phosphate + thioredoxin = acetyl phosphate + methylamine + thioredoxin disulfide
show the reaction diagram
-
S-adenosyl-L-methionine + N-methylglycine = S-adenosyl-L-homocysteine + N,N-dimethylglycine
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (14 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N,N-dimethylglycine + H2O + O2 = sarcosine + formaldehyde + H2O2
show the reaction diagram
-
S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + N-methylglycine
show the reaction diagram
-
-
N-carbamoylsarcosine + H2O = sarcosine + CO2 + NH3
show the reaction diagram
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creatine + H2O = sarcosine + urea
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (26 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
sarcosine + O2 + H2O = glycine + formaldehyde + H2O2
show the reaction diagram
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sarcosine + acceptor + H2O = glycine + formaldehyde + reduced acceptor
show the reaction diagram
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sarcosine + acceptor + H2O = ? + reduced acceptor
show the reaction diagram
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ATP + 5-phosphoribosylamine + sarcosine = ?
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (26 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
glyocylate + methylamine + NADPH + H+ = sarcosine + NADP+
show the reaction diagram
-
-
N,N-dimethylglycine + H2O + O2 = sarcosine + formaldehyde + H2O2
show the reaction diagram
-
S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine
show the reaction diagram
-
-
N-carbamoylsarcosine + H2O = sarcosine + CO2 + NH3
show the reaction diagram
-

Inhibitor in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
1 mM, 24% inhibition
-
competitive inhibition, versus glycine, 70% inhibition at 250 mM
slight competitive inhibition, versus dimethylglycine, 20% inhibition at 250 mM
-
slight inhibition
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weak
-

3D Structure of Enzyme-Ligand-Complex (PDB) (42 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (32 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
4
-
pH 10, temperature not specified in the publication
0.065
-
-
3.6
-
-

KM Value (73 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
3.7
-
pH 7.7, 37°C
25
-
pH 10, temperature not specified in the publication
3.14
-
pH 7.2, 37°C
1.2
-
-

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
405
-
pH 8.0, 25°C
130
-
-

References & Links

Links to other databases for sarcosine

ChEBI
PubChem
ChEBI
PubChem