Ligand oxaloacetate

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Basic Ligand Information

Molecular Structure
Picture of oxaloacetate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C4H4O5
oxaloacetate
KHPXUQMNIQBQEV-UHFFFAOYSA-N
Synonyms:
2-oxo-succinate, 2-oxobutan-1,4-dioate, 2-oxobutanedioate, 2-oxobutanedioic acid, 2-oxosuccinate, 2-oxosuccinic acid, 3-oxosuccinate, alpha-keto-succinate, keto-oxaloacetate, oxalacetate, oxalacetic acid, oxaloacetic acid
Pathway Source
Pathways
MetaCyc
(S)-lactate fermentation to propanoate, acetate and hydrogen, 2-methylcitrate cycle I, 2-methylcitrate cycle II, 3-methylarginine biosynthesis, acetyl-CoA biosynthesis from citrate more


Show all pahtways known for Show all BRENDA pathways known for oxaloacetate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (122 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
PROVEN IN VIVO REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
oxaloacetic acid + NAD+ = ?
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show the reaction diagram
Oxaloacetate = Pyruvate + CO2
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show the reaction diagram
oxaloacetate + NADH + H+ = malate + NAD+
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show the reaction diagram
(S)-lactate + oxaloacetate = malate + pyruvate
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show the reaction diagram
propionyl-CoA + oxaloacetate = (S)-methylmalonyl-CoA + pyruvate
show the reaction diagram
acetyl-CoA + H2O + oxaloacetic acid = ? + CoA
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show the reaction diagram
lauroyl-CoA + H2O + oxaloacetate = (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA
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show the reaction diagram
pyridoxamine + oxaloacetate = pyridoxal + L-aspartate
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show the reaction diagram
L-arogenate + oxaloacetate = L-aspartate + prephenate
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show the reaction diagram
oxaloacetate + H2O = oxalate + acetate
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show the reaction diagram
phosphate + oxaloacetate = phosphoenolpyruvate + HCO3-
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In Vivo Product in Enzyme-catalyzed Reactions (87 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
PROVEN IN VIVO REACTION
ENZYME 3D STRUCTURE
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show the reaction diagram
(S)-malate + NAD+ = oxaloacetate + NADH + H+
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show the reaction diagram
Pyruvate + CO2 = Oxaloacetate
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show the reaction diagram
(S)-malate + NADP+ = oxaloacetate + NADPH + H+
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show the reaction diagram
D-aspartic acid + H2O + O2 = oxaloacetate + NH3 + H2O2
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show the reaction diagram
L-Asp + H2O + O2 = oxaloacetate + NH3 + H2O2
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show the reaction diagram
D-aspartate + H2O + O2 = oxaloacetate + NH3 + H2O2
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show the reaction diagram
(S)-methylmalonyl-CoA + pyruvate = propanoyl-CoA + oxaloacetate
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show the reaction diagram
D-aspartate + 2-oxoglutarate = 2-oxosuccinate + D-glutamate
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show the reaction diagram
glyoxylate + L-aspartate = glycine + oxaloacetate
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show the reaction diagram
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate
show the reaction diagram
L-aspartate + 3-phenylpyruvate = oxaloacetate + L-phenylalanine
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prephenate + L-aspartate = L-arogenate + oxaloacetate
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show the reaction diagram
phosphate + phosphoenolpyruvate + CO2 = diphosphate + oxaloacetate
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show the reaction diagram
citrate = acetate + oxaloacetate
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4-carboxy-4-hydroxy-2-oxoadipate = oxaloacetate + pyruvate
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show the reaction diagram
L-tartrate = oxaloacetate + H2O
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show the reaction diagram
(S,S)-tartrate = oxaloacetate + H2O
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show the reaction diagram
L-threo-3-hydroxyaspartate = oxaloacetate + NH3
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Substrate in Enzyme-catalyzed Reactions (344 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
oxalacetic acid + NADPH = ? + NADP+
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show the reaction diagram
oxaloacetate + NADH H+ = ? + NAD+
show the reaction diagram
oxaloacetic acid + NAD+ = ?
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show the reaction diagram
oxaloacetate + NADPH = malate + NADP+
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oxaloacetate + NAD(P)H = malate + NAD(P)+
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show the reaction diagram
oxaloacetate + NADH + H+ = malate + NAD+
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show the reaction diagram
oxaloacetate + NADH = malate + NAD+
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D-2-hydroxyglutarate + oxaloacetate = 2-oxoglutarate + malate
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show the reaction diagram
(S)-lactate + oxaloacetate = malate + pyruvate
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oxaloacetate + CoA + NADP+ = ? + CO2 + NADPH
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oxaloacetate + H2O + methyl viologen = ?
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oxaloacetate + NH3 + NADH = L-Asp + H2O + NAD+
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2-oxosuccinic acid + NH3 + NADPH + H+ = ?
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show the reaction diagram
methylamine + oxaloacetate + NADPH = aspartic acid + H2O + NADP+
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show the reaction diagram
oxaloacetate + NADPH + NH3 = L-aspartate + NADP+ + H2O
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show the reaction diagram
oxaloacetate + NH3 + NADH + H+ = L-aspartate + H2O + NAD+
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L-Arg + oxaloacetate + NADH = ?
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L-Ala + oxaloacetate + NADH = ?
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taurine + oxaloacetate + NADH = ?
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L-ornithine + oxaloacetic acid + NADPH + H+ = ? + NADP+ + H2O
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show the reaction diagram
L-Met + oxaloacetate + NADH = ?
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(2S)-2-amino-4-[[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino]butanoate + oxaloacetate + NADPH + H+ = ? + NADP+ + H2O
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acetyl-CoA + H2O + oxaloacetic acid = ? + CoA
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acetyl-CoA + H2O + oxalacetic acid = ? + CoA
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show the reaction diagram
(S)-1-phenylethylamine + oxaloacetate = acetophenone + ?
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L-alanine + oxaloacetate = pyruvate + L-aspartate
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ornithine + oxaloacetate = DELTA1-pyrroline-5-carboxylate + L-aspartate
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L-glutamine + oxaloacetate = 2-oxoglutaramate + L-aspartate
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beta-alanine + oxaloacetic acid = malonic semialdehyde + L-aspartate
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show the reaction diagram
4-hydroxy-L-glutamate + oxaloacetate = 4-hydroxy-2-oxoglutarate + L-aspartate
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3,5-diiodo-L-tyrosine + oxaloacetate = 3,5-diiodo-4-hydroxyphenylpyruvate + L-aspartate
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L-3,5,3'-triiodothyronine + oxaloacetate = 3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-2-oxopropanoate + glycine
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show the reaction diagram
pyridoxamine + oxaloacetate = pyridoxal + L-aspartate
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show the reaction diagram
L-lysine + oxaloacetate = 2-aminoadipate 6-semialdehyde + L-aspartate
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show the reaction diagram
oxaloacetate + L-glutamate = 2-aminosuccinate + 2-oxoglutarate
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show the reaction diagram
(R)-3-amino-2-methylpropanoate + oxaloacetate = 2-methyl-3-oxopropanoate + L-aspartate
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D-methionine + oxaloacetate = 4-methylthio-2-oxobutanoate + L-aspartate
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3-(3,4-dihydroxyphenyl)-L-alanine + oxaloacetic acid = 3-(3,4-dihydroxyphenyl)pyruvate + L-aspartate
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L-serine + oxaloacetate = 3-hydroxypyruvate + L-aspartate
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L-leucine + oxaloacetate = 4-methyl-2-oxopentanoate + L-aspartate
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L-glutamine + oxaloacetate = 2-oxoglutaramate + L-aspartate
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L-methionine + oxaloacetate = 4-methylsulfanyl-2-oxobutanoate + L-aspartate
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show the reaction diagram
L-lysine + oxaloacetic acid = ?
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taurine + oxaloacetate = ?
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L-histidinol phosphate + oxaloacetate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-aspartate
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show the reaction diagram
(S)-1-phenylethylamine + oxaloacetate = acetophenone + L-aspartate
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show the reaction diagram
(2S,3S,5R,10S,12R,14R,15S,16S)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + oxaloacetate = (3S,5R,10S,12R,14R,15S,16S)-3,5,10,14,15-pentahydroxy-12,16-dimethylicosan-2-one + L-aspartate
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show the reaction diagram
acetyl-CoA + oxaloacetate = acetate + oxaloacetyl-CoA
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succinyl-CoA + oxaloacetate = oxaloacetyl-CoA + succinate
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oxaloacetate + H2O = oxalate + acetate
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oxaloacetate + H2O = ?
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show the reaction diagram
oxaloacetate = ?
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show the reaction diagram
oxaloacetate + NAD+ = ?
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show the reaction diagram
oxalacetate = oxalate + acetate
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show the reaction diagram
Oxaloacetate + glyoxylate = 3-Oxalomalate
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show the reaction diagram
Oxaloacetate = CO2 + pyruvate
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show the reaction diagram
Oxaloacetate = CO2 + pyruvate
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show the reaction diagram
acetate + oxaloacetate = citrate
show the reaction diagram
keto-Oxaloacetate = Enol-oxaloacetate
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show the reaction diagram
ATP + oxaloacetate + CoA = ADP + phosphate + oxaloacetyl-CoA
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Product in Enzyme-catalyzed Reactions (272 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE
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show the reaction diagram
Pyruvate + CO2 = Oxaloacetate
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show the reaction diagram
malate + NAD+ = 3-oxosuccinate + NADH + H+
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show the reaction diagram
DL-malate + acceptor = 2-oxosuccinate + reduced acceptor
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show the reaction diagram
D-malate + acceptor = oxaloacetate + reduced acceptor
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show the reaction diagram
pyruvate + L-malate = (S)-lactate + oxaloacetate
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show the reaction diagram
(S)-malate + O2 = oxaloacetate + H2O2
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L-Asp + H2O + NAD+ = oxaloacetate + NH3 + NADH
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show the reaction diagram
D-aspartic acid + H2O + O2 = oxaloacetate + NH3 + H2O2
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show the reaction diagram
D-Asp + H2O + oxidized 2,6-dichlorophenolindophenol = 2-oxobutanedioate + NH3 + reduced 2,6-dichlorophenolindophenol
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D-aspartate + oxidized 2,6-dichloroindophenol + H2O = oxaloacetate + NH3 + reduced 2,6-dichloroindophenol
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show the reaction diagram
(S)-methylmalonyl-CoA + pyruvate = propanoyl-CoA + oxaloacetate
show the reaction diagram
pyruvate + L-aspartate = L-alanine + oxaloacetate
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show the reaction diagram
beta-alanine + pyruvate = oxaloacetate + alanine
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L-aspartate + 2-oxoglutarate = 2-oxobutan-1,4-dioate + L-glutamate
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show the reaction diagram
glyoxylate + L-aspartate = glycine + oxaloacetate
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L-aspartate + 4,5-dioxopentanoate = 5-aminolevulinate + oxaloacetate
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show the reaction diagram
L-aspartate + glyoxylate = 2-oxosuccinate + glycine
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show the reaction diagram
3-(3,4-dihydroxyphenyl)pyruvate + L-aspartate = 3,4-dihydroxy-L-phenylalanine + oxaloacetate
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L-aspartate + pyruvate = oxaloacetate + L-alanine
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show the reaction diagram
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate
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D-aspartate + 2-oxoadipate = oxaloacetate + 2-aminoadipate
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L-aspartic acid + 2-oxoglutarate = oxaloacetate + L-glutamate
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show the reaction diagram
oxaloacetate 4-methyl ester = oxaloacetate + methanol
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Pyruvate + CO2 = Oxaloacetate
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show the reaction diagram
butynedioyl-CoA = oxaloacetate + CoA
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(2S,3S)-tartrate = oxaloacetate + H2O
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show the reaction diagram
(S,S)-tartrate = oxaloacetate + H2O
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show the reaction diagram
L-threo-3-hydroxyaspartate = oxaloacetate + NH3
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show the reaction diagram
L-aspartate + pyridoxal 5'-phosphate = 2-oxo-succinate + pyridoxamine 5'-phosphate
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show the reaction diagram
ATP + deamido-NAD+ + Asp = AMP + diphosphate + NAD+ + oxaloacetate
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show the reaction diagram
Pyruvate + CO2 = Oxaloacetate
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Activator in Enzyme-catalyzed Reactions (12 results)

COMMENTARY
EC NUMBER
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (320 results)

COMMENTARY
EC NUMBER
LITERATURE
ENZYME 3D STRUCTURE
50% inhibition at 0.91 mM
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50% inhibition at 2.5 mM
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inhibition at 5 mM
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