Ligand cadaverine

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Basic Ligand Information

Molecular Structure
Picture of cadaverine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H14N2
cadaverine
VHRGRCVQAFMJIZ-UHFFFAOYSA-N
Synonyms:
1,5-Diaminopentane, 1,5-pentanediamine, Diaminopentane, pentamethylenediamine


Show all pahtways known for Show all BRENDA pathways known for cadaverine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-adenosyl 3-(methylthio)propylamine + cadaverine = 5'-S-methyl-5'-thioadenosine + N-(3-aminopropyl)cadaverine
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cadaverine + pyruvate = 1-aminopentane + alanine
show the reaction diagram
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cadaverine + 2-oxoglutarate = 5-aminopentanal + L-glutamate
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-lysine = cadaverine + CO2
show the reaction diagram
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-

Substrate in Enzyme-catalyzed Reactions (30 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1,5-Diaminopentane + NADPH + O2 = ?
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cadaverine + O2 + H2O = 5-aminopentanal + NH3 + H2O2
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cadaverine + H2O + 2,6-dichlorophenol indophenol = ? + NH3 + reduced 2,6-dichlorophenol indophenol
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carbamoyl phosphate + cadaverine = phosphate + N-carbamoylcadaverine
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caffeoyl-CoA + cadaverine = CoA + N-caffeoylcadaverine
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acetyl-CoA + 1,5-pentanediamine = ?
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acetyl-CoA + 1,5-diaminopentane = CoA + N1-acetyl-1,5-diaminopentane
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S-adenosyl 3-(methylthio)propylamine + cadaverine = 5'-S-methyl-5'-thioadenosine + N-(3-aminopropyl)cadaverine
show the reaction diagram
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S-adenosyl-3-methylthio-1-propylamine + 1,5-diaminopentane = 5'-methylthioadenosine + N-(3-aminopropyl)-1,5-diaminopentane
show the reaction diagram
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cadaverine + pyruvate = 1-aminopentane + alanine
show the reaction diagram
-
cadaverine + propionaldehyde = ? + 1-aminopropane
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cadaverine + 2-oxoglutarate = 5-aminopentanal + L-glutamate
show the reaction diagram
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cadaverine + 2-oxoglutarate = L-glutamate + 5-aminopentanal
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (20 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acetylcadaverine + H2O = acetate + cadaverine
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acetylcadaverine + H2O = acetate + cadaverine
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acetylcadaverine + H2O = acetate + cadaverine
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1-amino-5-guanidinopentane + H2O = 1,5-diaminopentane + urea
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D-lysine = cadaverine + CO2
show the reaction diagram
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L-lysine = 1,5-diaminopentane + CO2
show the reaction diagram
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L-lysine = 1,5-diaminopentane + CO2
show the reaction diagram
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-

Activator in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
up to 40% stimulation at 1 mm
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can replace missing Mg2+ to a small extent
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Inhibitor in Enzyme-catalyzed Reactions (46 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
87% of initial activity at 0.5 mM
-
10 mM, causes 10-20% inhibition of carboxynorspermidine formation
-
noncompetitive against putrescine
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24% inhibition
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0.2 mM, 74% inhibition
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12 mM
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3 mM, 26% loss of activity
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10 mM, 80% inhibition in the presence of 0.5 mM N-acetyl-L-glutamate
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30% inhibition
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mixed type inhibition
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14% inhibition
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cadaverine; Ki: 1.5 mM
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3D Structure of Enzyme-Ligand-Complex (PDB) (7 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (13 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (37 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
7.7
-
-

Ki Value (7 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.28
-
-
0.038
-
pH 6.0, 25°C
0.04
-
-
0.058
-
-
1.5
-
-
0.46
-
recombinant enzyme, pH 7.5, 37°C
0.004
-
-

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.91
-
pH 8.5, 21°C

References & Links

Links to other databases for cadaverine

ChEBI
PubChem
ChEBI
PubChem