Ligand P1,P4-bis(5'-guanosyl) tetraphosphate

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Basic Ligand Information

Molecular Structure
Picture of P1,P4-bis(5'-guanosyl) tetraphosphate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C20H28N10O21P4
P1,P4-bis(5'-guanosyl) tetraphosphate
OLGWXCQXRSSQPO-MHARETSRSA-N
Synonyms:
1-P,4-P-bis(5'-guanosyl) tetraphosphate, 5',5'-P1,P4-diguanosine tetraphosphate, diguanosine 5',5'-P1,P4-tetraphosphate, diguanosine tetraphosphate, Gp4G, P1,P4-bis(5'-guanosyl)tetraphosphate, P1,P4-bis(5-guanosyl)tetraphosphate, P1,P4-diguanosine 5-tetraphosphate
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
GTP + GTP = diphosphate + P1,P4-bis(5'-guanosyl)tetraphosphate
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
Gp4G + H2O = GMP + GTP
show the reaction diagram
-
P1,P4-Bis(5'-guanosyl) tetraphosphate + H2O = GTP
show the reaction diagram
-
5'-adenylated cytidine 5',3'-bisphosphate + diguanosine tetraphosphate = Gp4GpCp + pCpGp4GpCp
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
IC50: 0.4 mM, 2 mM, approx. 80% inhibition
-

Enzyme Kinetic Parameters

KM Value (8 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
1.06
-
pH 5.9, 40C
4
-
pH 7.4, 30C

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.4
-
IC50: 0.4 mM, 2 mM, approx. 80% inhibition

References & Links

Links to other databases for P1,P4-bis(5'-guanosyl) tetraphosphate

ChEBI
PubChem
ChEBI
PubChem