Ligand (R)-reticuline

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Basic Ligand Information

Molecular Structure
Picture of (R)-reticuline (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C19H23NO4
(R)-reticuline
BHLYRWXGMIUIHG-OAHLLOKOSA-N

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(R)-reticuline + [reduced NADPH-hemoprotein reductase] + O2 = salutaridine + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
-
S-adenosyl-L-methionine + (R)-reticuline = S-adenosyl-L-homocysteine + (R)-laudanine
show the reaction diagram
-
S-adenosyl-L-methionine + (R)-reticuline = S-adenosyl-L-homocysteine + (S)-tembetarine
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1,2-dehydroreticulinium + NADPH + H+ = (R)-reticuline + NADP+
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(R)-reticuline + NADPH + H+ + O2 = salutaridine + NADP+ + 2 H2O
show the reaction diagram
-
S-adenosyl-L-methionine + (R)-reticuline = S-adenosyl-L-homocysteine + (R)-laudanine
show the reaction diagram
-
S-adenosyl-L-methionine + (R)-reticuline = S-adenosyl-L-homocysteine + (S)-tembetarine
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (3 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.027
-
-
0.07
-
pH 8.0, 35°C
0.053
-
pH 7.0, 30°C

KM Value (5 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.017
-
pH 8.0, 35°C
0.085
-
pH 7.0, 30°C

References & Links

Links to other databases for (R)-reticuline

ChEBI
PubChem
ChEBI
PubChem