Ligand D-erythrose 4-phosphate

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Basic Ligand Information

Molecular Structure
Picture of D-erythrose 4-phosphate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C4H9O7P
D-erythrose 4-phosphate
NGHMDNPXVRFFGS-IUYQGCFVSA-N
Synonyms:
(2R,3R)-2,3-dihydroxy-4-oxobutyl-phosphate, (2R,3R)-2,3-dihydroxy-4-oxobutyl phosphate, 4-O-phosphonato-D-erythrose, 4-phospho-D-erythrose, D-erythrose-4-phosphate


Show all pahtways known for Show all BRENDA pathways known for D-erythrose 4-phosphate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-erythrose 4-phosphate + NAD+ = 4-phosphoerythronate + NADH
show the reaction diagram
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D-erythrose 4-phosphate + D-fructose 6-phosphate = sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate
show the reaction diagram

In Vivo Product in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
FMNH2 + NADH + H+ + O2 = 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + NAD+ + ?
show the reaction diagram
-
-
sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate
show the reaction diagram
-
D-Fructose 6-phosphate + phosphate = Acetyl phosphate + D-erythrose 4-phosphate + H2O
show the reaction diagram
-
-
D-erythrulose 4-phosphate = D-erythrose 4-phosphate
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (32 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-erythrose 4-phosphate + NADPH + H+ = ? + NADP+
show the reaction diagram
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pyruvate + D-erythrose 4-phosphate = ?
show the reaction diagram
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D-erythrose 4-phosphate + D-xylulose 5-phosphate = D-fructose 6-phosphate + glyceraldehyde 3-phosphate
show the reaction diagram
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pyruvate + D-erythrose 4-phosphate = 1-deoxy-D-fructose 6-phosphate + CO2
show the reaction diagram
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D-erythrose 4-phosphate + H2O = D-erythrose + phosphate
show the reaction diagram
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D-erythrose 4-phosphate + H2O = D-erythrose + phosphate
show the reaction diagram
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D-erythrose-4-phosphate + H2O = D-erythrose + phosphate
show the reaction diagram
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Pyruvate + D-erythrose 4-phosphate = 3-Deoxy-D-riboheptulosonic acid 7-phosphate
show the reaction diagram
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D-Erythrose 4-phosphate + acetaldehyde = ?
show the reaction diagram
-
D-erythrose 4-phosphate = D-erythrulose 4-phosphate
show the reaction diagram
-
D-erythrose 4-phosphate = D-erythrulose 4-phosphate
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (24 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
FMNH2 + NADH + H+ + O2 = 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + NAD+ + ?
show the reaction diagram
-
-
sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate
show the reaction diagram
-
D-Fructose 6-phosphate + phosphate = Acetyl phosphate + D-erythrose 4-phosphate + H2O
show the reaction diagram
-
D-Fructose 6-phosphate + phosphate = Acetyl phosphate + D-erythrose 4-phosphate + H2O
show the reaction diagram
-
-
D-erythrulose 4-phosphate = D-erythrose 4-phosphate
show the reaction diagram
-
-

Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
slight activation
-
slight activation
-

Inhibitor in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive inhibition of aldolase activity
-
competitive
-

3D Structure of Enzyme-Ligand-Complex (PDB) (33 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (33 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.5
-
wild-type, pH 7.2, 25°C

KM Value (83 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.038
-
wild-type, pH 7.2, 25°C
0.12
-
pH 7.9, 37°C

Ki Value (4 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
TABLE ID
0.38
-
recombinant enzyme, pH 7.5, 50°C
9752
0.38
-
-
35424

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
3.7
-
Pdx1, pH 8.0, 37°C

References & Links

Links to other databases for D-erythrose 4-phosphate

ChEBI
PubChem
ChEBI
PubChem