Ligand ZnSO4

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Basic Ligand Information

Molecular Structure
Picture of ZnSO4 (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
H2O4SZn
ZnSO4
NWONKYPBYAMBJT-UHFFFAOYSA-L

Roles as Enzyme Ligand

Activator in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
152% activity at 1 mM
-

Inhibitor in Enzyme-catalyzed Reactions (149 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
at 5 mM 71-100% inhibition, depending on the substrate
-
complete inhibition of oxidation and 80% inhibition of reduction at 1.25 mM
-
1 mM, 80% inhibition, EDTA restores
-
10 mM, 21% inhibition
-
2 mM, 2% residual activity
-
28% inhibition at 1 mM
-
8% inhibition at 0.5 mM
-
sub mM concentration slight inhibition
-
10 mM, 0.5% inhibition
-
0.4 mM, 84% inhibition
-
95% inhibition at 0.1 mM, complete inhibition at 1 mM, 5 mM 2-oxoglutarate, 1 mM ferrous sulfate, 5 mM L-ascorbic acid, 100 mM TES pH 7.5, 30°C
-
1 mM, 80% inhibition
-
100% inhibition
-
26% remaining activity at an inhibitor concentration of 1 mM; 74% inhibtion at 1 mM
-
10 mM, almost complete inhibition
-
1 mM, 53% inhibition
-
0.1-1 mM
-
57% inhibition at 0.05 mM
-
0.1 mM, 98% inhibition
-
1 mM, 1 h at 22°C, 69% remaining activity
-
1 mM, no residual activity
-
0.003 mM, 82% inhibition
-
1 mM, 46% inhibition
-
3 mM
-
10 mM, 99% inhibition
-
1 mM, complete inhibition
-
7 mM, complete inhibition
-
inhibits 27% at 0.05 mM and 24.5% at 0.1 mM
-
68% residual activity at 10 mM
-
44% inhibition at 0.1 mM
-
1 mM, 38% inhibition
-
1 mM, 93% inhibition
-
0.1 mM, 90% inhibition
-
sensitive to 9 mM ZnSO4
-
59% inhibition at 1 mM; 65% inhibition at 1 mM
-
1 mM, 16% loss of activity
-
1 mM, 91% inhibition
-
2.5 mM, 59% inhibition
-
moderately inhibits phytase activity
-
2.5 mM, 59% inhibition
-
slight inhibition
-
10 mM, 21% inhibition
-
10 mM, 50% loss of activity
-
1 mM, complete inhibition
-
1 mM, 77% inhibition
-
1 mM, 19% inhibition of xylanase 2, no inhibition of xylanase 1
-
2 mM, enzyme activity 23%
-
24% residual activity at 1 mM
-
30°C, 10 min, 1 mM, 98% loss of activity
-
69% residual activity at 10 mM
-
complete inactivation at 1 mM
-
94% inhibition at 1 mM
-
87% inhibition at 1 mM, substrate Leu-2-N-naphthylamine
-
2 mM, activity decreases to less than 20% of the maximum
-
1 mM, incubation at 30°C for 10 min, complete inhibition
-
1 mM, 30.4% inhibition
-
1 mM, 98% inhibition
-
complete inhibition at 1 mM
-
reactivated by chelating agents
-
5 mM, 78% inhibition
-
1 mM, relative activity: 99.5%
-
0.1 mM, 90% decrease in activity
-
relative activity: 78%
-
weak
-
-
-
2 mM, complete inhibition
-

Metals and Ions (18 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
9% activation at 1 mM
-
1mM, 135% of initial activity
-
1 mM, 59% residual activity
-
14% activation at 0.1 mM, 82% activation at 10 mM
-
1 mM relative activity: 99.7%
-
activity 111%
-
activates
-
0.3 mM, about 2.5fold stimulation
-
1 mM, 211% of initial activity
-
5 mM, 1.26fold activation
-
0.5 mM, 25% stimulation
-
5 mM, 101.1% activity compared to activity without addition of MgCl2, 1.25 mM 4-nitrophenyl beta-D-xylopyranoside as substrate, pH 4.6, 40°C; 5 mM, 99.1% activity compared to activity without addition of MgCl2, 1.25 mM 4-nitrophenyl beta-D-xylopyranoside as substrate, pH 4.6, 42°C
-
5 mM, 111.4% activity compared to activity without addition of MgCl2, 1.25 mM 4-nitrophenyl beta-D-glucopyranoside as substrate, pH 4.6, 40°C; 5 mM, 90.2% activity compared to activity without addition of MgCl2, 1.25 mM 4-nitrophenyl beta-D-glucopyranoside as substrate, pH 4.6, 42°C
-
1 mM, 46% inhibition, isoenzyme MpiCP-2
-
0.1 mM, 108% reactivation of the enzyme inactivated by EDTA
-
activates
-
2.5 mM, 100% stimulation of activity
-
activity: 43%, crude: 100%
-

Enzyme Kinetic Parameters

Ki Value (3 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
1.4
-
prostaglandin D2 11-ketoreductase activity
0.00049
-
monoamine oxidase A
0.51
-
pH 9.5, 30°C

IC50 Value (2 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.005
-
value identical for wildtype and for mutant E154C
0.0034
-
in 25 mM potassium phosphate (pH 7.5), at 30°C

References & Links

Links to other databases for ZnSO4

ChEBI
PubChem
ChEBI
PubChem