Ligand dimethylarsinic acid

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Basic Ligand Information

Molecular Structure
Picture of dimethylarsinic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C2H7AsO2
dimethylarsinic acid
OGGXGZAMXPVRFZ-UHFFFAOYSA-N
Synonyms:
cacodylate, dimethylarsinate, dimethylarsonate, dimethylarsonous acid
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-adenosyl-L-methionine + methylarsonite = S-adenosyl-L-homocysteine + dimethylarsinate
show the reaction diagram
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-

Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-aspartate-4-semialdehyde + cacodylate + NADP+ = L-4-aspartyl cacodylate + NADPH
show the reaction diagram
dimethylarsonate + glutathione = dimethylarsonous acid
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dimethylarsonate + glutathione = dimethylarsonous acid
show the reaction diagram
-
-

Inhibitor in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
binding mechanism
-
134 mM
-

3D Structure of Enzyme-Ligand-Complex (PDB) (198 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

KM Value (2 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
140
-
recombinant wild-type enzyme, pH 9.0, 30°C
20.9
-
-

Ki Value (4 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
5.6
-
-
12
-
recombinant enzyme, pH 6.4

References & Links

Links to other databases for dimethylarsinic acid

ChEBI
PubChem
ChEBI
PubChem