Ligand TLCK

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Basic Ligand Information

Molecular Structure
Picture of TLCK (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C14H20ClNO3S
TLCK
TYQCGWOGNUOQAR-ZDUSSCGKSA-N
Synonyms:
N-alpha-p-tosyl-L-leucine-chloromethylketone, N-alpha-tosyl-L-Leu chloromethyl ketone, N-[(1S)-1-(chloroacetyl)-3-methylbutyl]-4-methylbenzenesulfonamide, Nalpha-tosyl-L-Leu chloromethyl ketone, tosyl-L-Leu-chloromethylketone, tosyl-L-Leu chloromethyl ketone, tosyl-L-leucine-chloromethyl ketone, tosyl-L-leucinechloromethyl ketone, tosyl-L-leucine chloromethyl ketone, tosyl-Leu-CH2Cl, tosyl-Leu chloromethyl ketone, tosylsulfonylleucylchloromethyl ketone

Roles as Enzyme Ligand

Inhibitor in Enzyme-catalyzed Reactions (42 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
72.15% residual activity at 10 mM
-
IC50: 0.3 mM
-
1.0 mM inhibitor, 27% inhibition, 5.0 mM inhibitor, 63% inhibition
-
irreversble
-
1 mM, 10% loss of activity
-
10 mM, 18% inhibition
-
0.1 mM, 73.2% inhibition
-
0.2 mM, complete inhibition
-
total loss of enzyme activity
-
14% inhibition at 0.2 mM
-
10 mM, less than 10% residual activity
-
0.2 mM, 51% inhibition
-
0.1 mM, complete inhibition
-
i.e. TLCK
-
0.1 mM, 60-80% inhibition
-
0.1 mM, 60-80% inhibition
-
93.3% residual activity at 5 mM
-
markedly decreases enzymatic activity
-
0.133 mg/ml, 79.57% inhibition
-
5 mM, 12% of initial activity
-
12.5 mM, 98% inhibition
-
1 mM, complete inhibition
-

Enzyme Kinetic Parameters

IC50 Value (2 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.3
-
IC50: 0.3 mM
1.2
-
pH 8.0, 37°C

References & Links

Links to other databases for TLCK

ChEBI
PubChem
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PubChem