Ligand ethanolamine

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Basic Ligand Information

Molecular Structure
Picture of ethanolamine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C2H7NO
ethanolamine
HZAXFHJVJLSVMW-UHFFFAOYSA-N
Synonyms:
2-Aminoethanol, Aminoethanol, Monoethanolamine


Show all pahtways known for Show all BRENDA pathways known for ethanolamine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ethanolamine + H2O + O2 = glycolaldehyde + NH3 + H2O2
show the reaction diagram
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ethanolamine + ATP = O-phosphoethanolamine + ADP
show the reaction diagram
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ATP + ethanolamine = ADP + O-phosphoethanolamine
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (22 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-1-phosphatidylethanolamine + L-serine = L-1-phosphatidylserine + ethanolamine
show the reaction diagram
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a phosphatidylglycerol + a phosphatidylethanolamine = a cardiolipin + ethanolamine
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glycero-3-phosphoethanolamine + H2O = sn-glycerol-3-phosphate + ethanolamine
show the reaction diagram
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1-alkyl-sn-glycero-3-phosphoethanolamine + H2O = 1-alkyl-sn-glycerol 3-phosphate + ethanolamine
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anandamide + H2O = arachidonic acid + ethanolamine
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Substrate in Enzyme-catalyzed Reactions (24 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-aminoethanol + NAD+ = ?
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monoethanolamine + O2 = aminoacetaldehyde + H2O2
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ethanolamine + H2O + O2 = glycolaldehyde + NH3 + H2O2
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ethanolamine + H2O + O2 = glycolaldehyde + NH3 + H2O2
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ethanolamine + H2O + O2 = glycolaldehyde + NH3 + H2O2
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arginine + ethanolamine = 2-guanidinoethanol + ornithine
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phosphatidylcholine + ethanolamine = phosphatidylethanolamine + choline
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mesaconate + 2-aminoethanol = ?
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ATP + gamma-L-Glu-L-Cys + ethanolamine = ADP + phosphate + gamma-Glu-L-Cys-ethanolamine
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Product in Enzyme-catalyzed Reactions (68 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
taurine + 2-oxoglutarate + O2 = succinate + CO2 + aminoethanol + sulfite
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L-1-phosphatidylethanolamine + L-serine = L-1-phosphatidylserine + ethanolamine
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phosphoethanolamine + H2O = phosphate + ethanolamine
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N-hydroxyethylammelide + H2O = cyanuric acid + 2-aminoethanol
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2-phosphorylethanolamine + H2O = ethanolamine + phosphate
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2-hydroxy-4,6-di(N-hydroxyethylamino)-1,3,5-triazine + H2O = 6-[(2-hydroxyethyl)amino]-1,3,5-triazine-2,4-diol + 2-aminoethanol
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DL-2-amino-3-(N-hydroxyethylamino)-propionic acid = ethanolamine + NH3 + pyruvate
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Activator in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
alphaH44A mutant, works as catalytic base
-
activates
-
induces a 15fold increase in the rate of autophosphorylation in vitro of the HK17 sensor histidine kinase
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234% activation of recombinant refolded enzyme at 30% v/v, 37% at 10% v/v
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activates
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stimulates activity of mutant enzyme Lys265Arg
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Inhibitor in Enzyme-catalyzed Reactions (37 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
1 mM, 70% inhibition
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100 mM, 35% inhibition
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; 45% inhibition at 250 mM, with glycine
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about 37% inhibition at 100 mM
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about 70% inhibition of isomaltase activity by 50 mM
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strong inhibition
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supresses cleavage by dS1P
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markedly lower activity
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weak
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10 mM, 17% loss of activity
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3D Structure of Enzyme-Ligand-Complex (PDB) (2 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (28 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
3.3
-
isoform AO1, in 200 mM potassium phosphate buffer pH 7.6, at 30°C

KM Value (52 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
2.05
-
isoform AO1, in 200 mM potassium phosphate buffer pH 7.6, at 30°C
2
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at pH 7.0 and 37°C

Ki Value (9 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
78
-
-
2.2
9
pH 8.0, 37°C
19.3
-
-

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
1.77
-
pH 8.5, 21°C

References & Links

Links to other databases for ethanolamine

ChEBI
PubChem
ChEBI
PubChem