Ligand dCMP

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Basic Ligand Information

Molecular Structure
Picture of dCMP (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C9H14N3O7P
dCMP
NCMVOABPESMRCP-SHYZEUOFSA-N
Synonyms:
(d)CMP, 2'-deoxy-CMP, 2'-deoxycytidine 5'-monophosphate, 2'-deoxycytidine 5'-phosphate, 5'-dCMP, 5'-deoxy CMP, a nucleoside monophosphate, a nucleoside phosphate, D-2'-deoxycytidine 5'-phosphate, D-dCMP, deoxycytidine monophosphate, deoxycytidylate, E-dCMP


Show all pahtways known for Show all BRENDA pathways known for dCMP

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5,10-methylenetetrahydrofolate + dCMP = dihydrofolate + deoxy-5-methylcytidylate
show the reaction diagram
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ATP + dCMP = ADP + dCDP
show the reaction diagram
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ATP + dCMP = ADP + dCDP
show the reaction diagram
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ATP + dCMP = ADP + dCDP
show the reaction diagram
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5'-dCMP + H2O = 2'-deoxycytidine + phosphate
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dCMP + H2O = dUMP + NH3
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (24 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + 2'-deoxycytidine = ADP + 2'-deoxycytidine 5'-phosphate
show the reaction diagram
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ATP + 2'-deoxycytidine = ADP + 2'-deoxycytidine 5'-phosphate
show the reaction diagram
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ATP + 2'-deoxycytidine = ADP + 2'-deoxycytidine 5'-phosphate
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dCTP + H2O = dCMP + diphosphate
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dCDP + H2O = dCMP + phosphate
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dCTP + H2O = dCMP + diphosphate
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Substrate in Enzyme-catalyzed Reactions (37 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5,10-methylenetetrahydrofolate + dCMP = dihydrofolate + deoxy-5-methylcytidylate
show the reaction diagram
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5'-dCMP + thymidine = 2'-deoxycytidine + TMP
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ATP + dCMP = ADP + dCDP
show the reaction diagram
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ATP + dCMP = ADP + dCDP
show the reaction diagram
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ATP + dCMP = ADP + dCDP
show the reaction diagram
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dCMP + [phosphate]n = dCDP + [phosphate]n-1
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5'-dCMP + H2O = deoxycytidine + phosphate
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5'-deoxy CMP + H2O = cytosine + deoxyribose 5-phosphate
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dCMP + H2O = dUMP + NH3
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Product in Enzyme-catalyzed Reactions (110 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
CMP + reduced thioredoxin = dCMP + oxidized thioredoxin + H2O
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TTP + dCMP = TDP + dCMP
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dCDP-diacylglycerol + sn-glycero-3-phosphate = dCMP + phosphatidylglycerophosphate
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2'-deoxycytidine 3',5'-bisphosphate + H2O = 2'-deoxycytidine 5'-phosphate + phosphate
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polydeoxycytosylic acid + H2O = 5'-dCMP + 5'-phosphooligonucleotides
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oligonucleotides + H2O = dCMP + dTMP
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dCTP + H2O = dCMP + diphosphate
show the reaction diagram
dCDP + H2O = dCMP + phosphate
show the reaction diagram
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dCTP + H2O = dCMP + diphosphate
show the reaction diagram
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dCTP + H2O = dCMP + diphosphate
show the reaction diagram
-
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Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
10 mM, 409% activation of deoxyadenosine phosphorylation, half-maximal activation at 1.6 mM
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allosterically increases dCMPD activity
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Inhibitor in Enzyme-catalyzed Reactions (30 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
5 mM, 26% inhibition
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allosteric inhibition
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weak inhibition
0.01 mM, 88% inhibition
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competitive, dTMP as substrate
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competitive inhibition of UMP phosphorylation
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10-15% inhibition at 5 mM
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inhibits uridylyl removing activity
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effective inhibition in presence of 1 mM GTP, noncompetitive inhibitor
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competitive inhibition of hydrolysis of dCTP and dCDP

3D Structure of Enzyme-Ligand-Complex (PDB) (14 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (35 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.0231
-
pH 7.5, 37°C, recombinant wild-type enzyme
0.23
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pH 8.0, 37°C, YfbR, with Co2+
0.23
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+/- 0.01
24.9
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pH 9.5, 42°C, in presence of 0.1 mM dCTP

KM Value (84 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.15
-
mutant TS N229D
0.0313
-
-
0.36
-
-
4
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pH 7.5, 37°C, recombinant wild-type enzyme
0.76
-
pH 9.5, 42°C, in presence of 0.1 mM dCTP
0.055
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pH 7.0, 37°C

Ki Value (4 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
TABLE ID
0.032
-
dTMP as substrate, pH 7.6, 37°C
15592
0.1633
-
pH 7.6, 37°C
39876

References & Links

Links to other databases for dCMP

ChEBI
PubChem
ChEBI
PubChem